Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893700263> ?p ?o ?g. }
- W2893700263 endingPage "37" @default.
- W2893700263 startingPage "29" @default.
- W2893700263 abstract "Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels of DRD are often confounded with prior drug use, and previous studies have also had limited genomic scope. The current investigation sought to address these issues by studying DRD in healthy young adults with low levels of substance use (N = 986; 62% female, 100% European ancestry) and investigating genetic variation genome-wide. The genome-wide approach used a prioritized subset design, organizing the tests into theoretically and empirically informed categories and apportioning power accordingly. Three subsets were used: (a) a priori loci implicated by previous studies; (b) high-value addiction (HVA) markers from the recently developed SmokeScreen array; and (c) an atheoretical genome-wide scan. Among a priori loci, a nominally significant association was present between DRD and rs521674 in ADRA2A. No significant HVA loci were detected. One statistically significant genome-wide association was detected (rs13395777, p = 2.8 × 10-8), albeit in an intergenic region of unknown function. These findings are generally not supportive of the previous candidate gene studies and suggest that DRD has a complex genetic architecture that will require considerably larger samples to identify genetic associations more definitively. (PsycINFO Database Record (c) 2019 APA, all rights reserved)." @default.
- W2893700263 created "2018-10-05" @default.
- W2893700263 creator A5028222906 @default.
- W2893700263 creator A5031236440 @default.
- W2893700263 creator A5041945807 @default.
- W2893700263 creator A5045220576 @default.
- W2893700263 creator A5051283952 @default.
- W2893700263 creator A5059782989 @default.
- W2893700263 date "2019-02-01" @default.
- W2893700263 modified "2023-10-17" @default.
- W2893700263 title "Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach." @default.
- W2893700263 cites W1506339020 @default.
- W2893700263 cites W1533659445 @default.
- W2893700263 cites W1580088926 @default.
- W2893700263 cites W1688546740 @default.
- W2893700263 cites W1920433988 @default.
- W2893700263 cites W1965505483 @default.
- W2893700263 cites W1966023927 @default.
- W2893700263 cites W1968161699 @default.
- W2893700263 cites W1969396463 @default.
- W2893700263 cites W1976877844 @default.
- W2893700263 cites W1980168725 @default.
- W2893700263 cites W1986084171 @default.
- W2893700263 cites W1990027430 @default.
- W2893700263 cites W1990434023 @default.
- W2893700263 cites W1991281276 @default.
- W2893700263 cites W1992488100 @default.
- W2893700263 cites W1994365387 @default.
- W2893700263 cites W1996296330 @default.
- W2893700263 cites W2010687330 @default.
- W2893700263 cites W2011068737 @default.
- W2893700263 cites W2011781973 @default.
- W2893700263 cites W2012139443 @default.
- W2893700263 cites W2017857669 @default.
- W2893700263 cites W2026271277 @default.
- W2893700263 cites W2028243322 @default.
- W2893700263 cites W2030271725 @default.
- W2893700263 cites W2031048386 @default.
- W2893700263 cites W2032471892 @default.
- W2893700263 cites W2032592703 @default.
- W2893700263 cites W2033151532 @default.
- W2893700263 cites W2034538919 @default.
- W2893700263 cites W2041978809 @default.
- W2893700263 cites W2049171896 @default.
- W2893700263 cites W2051132981 @default.
- W2893700263 cites W2054856852 @default.
- W2893700263 cites W2057737217 @default.
- W2893700263 cites W2066307049 @default.
- W2893700263 cites W2068210401 @default.
- W2893700263 cites W2073363296 @default.
- W2893700263 cites W2082051191 @default.
- W2893700263 cites W2086982304 @default.
- W2893700263 cites W2087036932 @default.
- W2893700263 cites W2088007293 @default.
- W2893700263 cites W2089217485 @default.
- W2893700263 cites W2091710728 @default.
- W2893700263 cites W2095859808 @default.
- W2893700263 cites W2096440877 @default.
- W2893700263 cites W2099085143 @default.
- W2893700263 cites W2104155147 @default.
- W2893700263 cites W2108065192 @default.
- W2893700263 cites W2109691697 @default.
- W2893700263 cites W2110608362 @default.
- W2893700263 cites W2113324723 @default.
- W2893700263 cites W2118082971 @default.
- W2893700263 cites W2118475046 @default.
- W2893700263 cites W2121323687 @default.
- W2893700263 cites W2126405975 @default.
- W2893700263 cites W2127624191 @default.
- W2893700263 cites W2132004093 @default.
- W2893700263 cites W2132145985 @default.
- W2893700263 cites W2133409124 @default.
- W2893700263 cites W2134186407 @default.
- W2893700263 cites W2137767247 @default.
- W2893700263 cites W2141749392 @default.
- W2893700263 cites W2144085253 @default.
- W2893700263 cites W2152023371 @default.
- W2893700263 cites W2155496693 @default.
- W2893700263 cites W2157752701 @default.
- W2893700263 cites W2158728518 @default.
- W2893700263 cites W2162224007 @default.
- W2893700263 cites W2163184920 @default.
- W2893700263 cites W2169288438 @default.
- W2893700263 cites W2169900764 @default.
- W2893700263 cites W2177434524 @default.
- W2893700263 cites W2181179802 @default.
- W2893700263 cites W2284353620 @default.
- W2893700263 cites W2320817721 @default.
- W2893700263 cites W2322947818 @default.
- W2893700263 cites W2323201411 @default.
- W2893700263 cites W2323215006 @default.
- W2893700263 cites W2346626662 @default.
- W2893700263 cites W2481801165 @default.
- W2893700263 cites W2492643729 @default.
- W2893700263 cites W2551092411 @default.
- W2893700263 cites W2564507066 @default.
- W2893700263 cites W2566905302 @default.
- W2893700263 cites W32483255 @default.