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- W2893707069 abstract "Sensitive, reliable, and selective detection of biochemical markers represents a challenging approach toward early diagnosis of cancer diseases. However, the complexity of the targeted physiological environments challenges currently available protocols. Therefore, new, reliable methodologies for the detection of cancer markers are highly demanded. Here, we describe a new method for parallel analysis of two essential cancer markers, HER2 (human epidermal growth factor receptor 2) and EpCAM (epithelial cell adhesion molecule). The method is based on a combination of a Fe2O3@Ag magnetic nanocomposite covalently functionalized with anti-EpCAM and anti-HER2, and surface-enhanced Raman spectroscopy. The detection of target molecules employs a competitive approach between reference compounds, labeled with Raman active tags, and their naturally accruing counterparts. The limit of detection was determined to be 5 ng L−1, where both compounds are statistically distinguishable from a blank sample with p = 0.0093 (HER2) and 0.0016 (EpCAM). The developed methodology presents an exciting alternative to more common methods including immunological methods or PCR." @default.
- W2893707069 created "2018-10-05" @default.
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- W2893707069 date "2018-12-01" @default.
- W2893707069 modified "2023-10-10" @default.
- W2893707069 title "Multiplex competitive analysis of HER2 and EpCAM cancer markers in whole human blood using Fe2O3@Ag nanocomposite" @default.
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- W2893707069 doi "https://doi.org/10.1016/j.apmt.2018.08.016" @default.
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