FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893709107> ?p ?o ?g. }

• W2893709107 abstract "Hematopoietic stem and progenitor cell (HSPC) compartments are altered to direct immune responses to infection. Their roles during immunization are not well described. To elucidate mechanisms for waning immunity following immunization with acellular vaccines (ACVs) against Bordetella pertussis (Bp), we tested the hypothesis that immunization with Bp ACVs and whole cell vaccines (WCVs) differ in directing the HSPC characteristics and immune cell development patterns that ultimately contribute to the types and quantities of cells produced to fight infection. Our data demonstrate that compared to control and ACV-immunized CD-1 mice, immunization with an efficacious WCV drives expansion of hematopoietic multipotent progenitor cells (MPPs), increases circulating white blood cells (WBCs), and alters the size and composition of lymphoid organs. In addition to MPPs, common lymphoid progenitor (CLP) proportions increase in the bone marrow of WCV-immunized mice, while B220+ cell proportions decrease. Upon subsequent infection, increases in maturing B cell populations are striking in WCV-immunized mice. RNAseq analyses of HSPCs revealed that WCV and ACV-immunized mice vastly differ in developing VDJ gene segment diversity. Moreover, gene set enrichment analyses demonstrate WCV-immunized mice exhibit unique gene signatures that suggest roles for interferon (IFN) induced gene expression. Also observed in naïve infection, these IFN stimulated gene (ISG) signatures point toward roles in cell survival, cell cycle, autophagy, and antigen processing and presentation. Taken together, these findings underscore the impact of vaccine antigen and adjuvant content on skewing and/or priming HSPC populations for immune response." @default.
• W2893709107 created "2018-10-05" @default.
• W2893709107 creator A5002420510 @default.
• W2893709107 creator A5013321799 @default.
• W2893709107 creator A5020318714 @default.
• W2893709107 creator A5025886581 @default.
• W2893709107 creator A5038258355 @default.
• W2893709107 creator A5058720494 @default.
• W2893709107 creator A5060350679 @default.
• W2893709107 creator A5065176157 @default.
• W2893709107 creator A5068524960 @default.
• W2893709107 creator A5069467530 @default.
• W2893709107 creator A5077458523 @default.
• W2893709107 creator A5082265556 @default.
• W2893709107 date "2018-10-18" @default.
• W2893709107 modified "2023-10-16" @default.
• W2893709107 title "Bordetella pertussis Whole Cell Immunization, Unlike Acellular Immunization, Mimics Naïve Infection by Driving Hematopoietic Stem and Progenitor Cell Expansion in Mice" @default.
• W2893709107 cites W1530235393 @default.
• W2893709107 cites W1604691790 @default.
• W2893709107 cites W1832214401 @default.
• W2893709107 cites W1834969374 @default.
• W2893709107 cites W1927634469 @default.
• W2893709107 cites W1941562760 @default.
• W2893709107 cites W1964057155 @default.
• W2893709107 cites W1970883851 @default.
• W2893709107 cites W1973099013 @default.
• W2893709107 cites W1977409139 @default.
• W2893709107 cites W1992907775 @default.
• W2893709107 cites W2004150448 @default.
• W2893709107 cites W2008727517 @default.
• W2893709107 cites W2009101093 @default.
• W2893709107 cites W2011059916 @default.
• W2893709107 cites W2015585437 @default.
• W2893709107 cites W2019892329 @default.
• W2893709107 cites W2020515234 @default.
• W2893709107 cites W2021821241 @default.
• W2893709107 cites W2027706002 @default.
• W2893709107 cites W2032923651 @default.
• W2893709107 cites W2036463856 @default.
• W2893709107 cites W2038920846 @default.
• W2893709107 cites W2039638385 @default.
• W2893709107 cites W2043306632 @default.
• W2893709107 cites W2045000380 @default.
• W2893709107 cites W2045089341 @default.
• W2893709107 cites W2055203089 @default.
• W2893709107 cites W2062391011 @default.
• W2893709107 cites W2066756683 @default.
• W2893709107 cites W2072411272 @default.
• W2893709107 cites W2074567852 @default.
• W2893709107 cites W2082589834 @default.
• W2893709107 cites W2089041106 @default.
• W2893709107 cites W2093901235 @default.
• W2893709107 cites W2100820895 @default.
• W2893709107 cites W2102476838 @default.
• W2893709107 cites W2108152721 @default.
• W2893709107 cites W2116797415 @default.
• W2893709107 cites W2118814125 @default.
• W2893709107 cites W2126756402 @default.
• W2893709107 cites W2146952542 @default.
• W2893709107 cites W2149053153 @default.
• W2893709107 cites W2152385842 @default.
• W2893709107 cites W2155510706 @default.
• W2893709107 cites W2158985300 @default.
• W2893709107 cites W2165705942 @default.
• W2893709107 cites W2169023984 @default.
• W2893709107 cites W2174440126 @default.
• W2893709107 cites W2185265351 @default.
• W2893709107 cites W2336656712 @default.
• W2893709107 cites W2398280244 @default.
• W2893709107 cites W2493524203 @default.
• W2893709107 cites W2510120973 @default.
• W2893709107 cites W2576546063 @default.
• W2893709107 cites W2596769025 @default.
• W2893709107 cites W2612082723 @default.
• W2893709107 cites W2612422581 @default.
• W2893709107 cites W2738966469 @default.
• W2893709107 cites W2744171534 @default.
• W2893709107 cites W2783711120 @default.
• W2893709107 doi "https://doi.org/10.3389/fimmu.2018.02376" @default.
• W2893709107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6200895" @default.
• W2893709107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30405604" @default.
• W2893709107 hasPublicationYear "2018" @default.
• W2893709107 type Work @default.
• W2893709107 sameAs 2893709107 @default.
• W2893709107 citedByCount "8" @default.
• W2893709107 countsByYear W28937091072019 @default.
• W2893709107 countsByYear W28937091072020 @default.
• W2893709107 countsByYear W28937091072021 @default.
• W2893709107 countsByYear W28937091072022 @default.
• W2893709107 crossrefType "journal-article" @default.
• W2893709107 hasAuthorship W2893709107A5002420510 @default.
• W2893709107 hasAuthorship W2893709107A5013321799 @default.
• W2893709107 hasAuthorship W2893709107A5020318714 @default.
• W2893709107 hasAuthorship W2893709107A5025886581 @default.
• W2893709107 hasAuthorship W2893709107A5038258355 @default.
• W2893709107 hasAuthorship W2893709107A5058720494 @default.
• W2893709107 hasAuthorship W2893709107A5060350679 @default.
• W2893709107 hasAuthorship W2893709107A5065176157 @default.
• W2893709107 hasAuthorship W2893709107A5068524960 @default.
• W2893709107 hasAuthorship W2893709107A5069467530 @default.

• next