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• W2893710195 abstract "Tau protein aggregation is believed to be one of the key drivers of Alzheimer's disease. The two hexapeptide amino acid sequences 306 VQIVYK 311 and 275 VQIINK 280 of the tau protein are responsible for aggregation, and subsequent functional loss leading to Alzheimer's progression. Hence, it is important to understand the factors that promote the self‐aggregation of this tau peptide fragments. Cellular microenvironmental polyanions are known to play a major role in tau protein aggregation and loss of function. Previous studies mainly focused on the effect of heparin and heparan sulfate solution on the full tau protein aggregation. Here, we study the effect of cellular polyanion mimetics, glycosaminoglycans (GAGs) in solution and on surface to mimic intracellular and extracellular conditions, and cellular RNA on the aggregation of tau hexapeptide 306 VQIVYK 311 , and mutant tau peptide 273 GKVQIIN_KLDL 284 found frequently in taupathy. Characterization techniques used for the study include biochemical assays, electron microscopy, and spectroscopy techniques to investigate the aggregation vitro. Results show while all the GAGs in solution form play a role in tau peptides aggregation, heparin, chondroitin sulfate, and dermatan sulfate in particular significantly promote the tau peptides aggregation formation. On the other hand, surface‐coated GAGs did not promote significant tau aggregation. As far as cellular RNA is concerned, results show significant increase in tau peptides aggregation and toxicity in neuroblastoma cells. The study on the tau peptides fragments aggregation in the presence of GAGs and cellular RNA could provide novel information on the tau aggregation mechanism and could open ways for developing cellular polyanions modulating therapeutics for treating Alzheimer's disease." @default.
• W2893710195 created "2018-10-05" @default.
• W2893710195 creator A5044572947 @default.
• W2893710195 creator A5088825318 @default.
• W2893710195 date "2018-09-24" @default.
• W2893710195 modified "2023-10-14" @default.
• W2893710195 title "Effect of cellular polyanion mimetics on tau peptide aggregation" @default.
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• W2893710195 doi "https://doi.org/10.1002/psc.3125" @default.
• W2893710195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30251388" @default.
• W2893710195 hasPublicationYear "2018" @default.
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