FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893717441> ?p ?o ?g. }

• W2893717441 abstract "Filamentous fungi are the most important microorganisms for the industrial production of plant polysaccharide degrading enzymes due to their unique ability to secrete these proteins efficiently. These carbohydrate active enzymes (CAZymes) are utilized industrially for the hydrolysis of plant biomass for the subsequent production of biofuels and high-value biochemicals. The expression of the genes encoding plant biomass degrading enzymes is tightly controlled. Naturally, large amounts of CAZymes are produced and secreted only in the presence of the plant polysaccharide they specifically act on. The signal to produce is conveyed via so-called inducer molecules which are di- or mono-saccharides (or derivatives thereof) released from the specific plant polysaccharides. The presence of the inducer results in the activation of a substrate-specific transcription factor (TF), which is required for the controlled expression of the genes encoding not only the CAZymes, but also the transporters and catabolic pathway enzymes needed to utilize the released monosaccharide. Over the years, several substrate-specific TFs involved in the degradation of cellulose, hemicellulose, pectin, starch and inulin have been identified in several fungal species and systems biology approaches have made it possible to uncover the enzyme networks controlled by these TFs. The requirement for specific inducers for TF activation and subsequently the expression of particular enzyme networks determines the choice of feedstock to produce enzyme cocktails for industrial use. It also results in batch-to-batch variation in the composition and amounts of enzymes due to variations in sugar composition and polysaccharide decorations of the feedstock which hampers the use of cheap feedstocks for constant quality of enzyme cocktails. It is therefore of industrial interest to produce specific enzyme cocktails constitutively and independently of inducers. In this review, we focus on the methods to modulate TF activities for inducer-independent production of CAZymes and highlight various approaches that are used to construct strains displaying constitutive expression of plant biomass degrading enzyme networks. These approaches and combinations thereof are also used to construct strains displaying increased expression of CAZymes under inducing conditions, and make it possible to design strains in which different enzyme mixtures are simultaneously produced independently of the carbon source." @default.
• W2893717441 created "2018-10-05" @default.
• W2893717441 creator A5048694693 @default.
• W2893717441 creator A5072964205 @default.
• W2893717441 date "2018-09-25" @default.
• W2893717441 modified "2023-09-25" @default.
• W2893717441 title "Modulating Transcriptional Regulation of Plant Biomass Degrading Enzyme Networks for Rational Design of Industrial Fungal Strains" @default.
• W2893717441 cites W1465481699 @default.
• W2893717441 cites W1494490236 @default.
• W2893717441 cites W1700615994 @default.
• W2893717441 cites W1807392324 @default.
• W2893717441 cites W1893029633 @default.
• W2893717441 cites W1971750302 @default.
• W2893717441 cites W1978774293 @default.
• W2893717441 cites W1981433254 @default.
• W2893717441 cites W1982772373 @default.
• W2893717441 cites W1992725305 @default.
• W2893717441 cites W1993494137 @default.
• W2893717441 cites W1994225991 @default.
• W2893717441 cites W1996800472 @default.
• W2893717441 cites W2002364176 @default.
• W2893717441 cites W2009662469 @default.
• W2893717441 cites W2011131041 @default.
• W2893717441 cites W2014441764 @default.
• W2893717441 cites W2015133493 @default.
• W2893717441 cites W2036543037 @default.
• W2893717441 cites W2046977847 @default.
• W2893717441 cites W2048009049 @default.
• W2893717441 cites W2049144064 @default.
• W2893717441 cites W2051381961 @default.
• W2893717441 cites W2055107331 @default.
• W2893717441 cites W2063833575 @default.
• W2893717441 cites W2064533850 @default.
• W2893717441 cites W2064938664 @default.
• W2893717441 cites W2068579855 @default.
• W2893717441 cites W2071948461 @default.
• W2893717441 cites W2074922493 @default.
• W2893717441 cites W2080310153 @default.
• W2893717441 cites W2080479472 @default.
• W2893717441 cites W2081725566 @default.
• W2893717441 cites W2082124679 @default.
• W2893717441 cites W2082591769 @default.
• W2893717441 cites W2083103761 @default.
• W2893717441 cites W2090080360 @default.
• W2893717441 cites W2090184326 @default.
• W2893717441 cites W2096261603 @default.
• W2893717441 cites W2104523295 @default.
• W2893717441 cites W2106728647 @default.
• W2893717441 cites W2111080711 @default.
• W2893717441 cites W2112621436 @default.
• W2893717441 cites W2113803821 @default.
• W2893717441 cites W2117255121 @default.
• W2893717441 cites W2118481109 @default.
• W2893717441 cites W2119851204 @default.
• W2893717441 cites W2119938020 @default.
• W2893717441 cites W2120666374 @default.
• W2893717441 cites W2120814647 @default.
• W2893717441 cites W2121307814 @default.
• W2893717441 cites W2121772614 @default.
• W2893717441 cites W2121841119 @default.
• W2893717441 cites W2122559203 @default.
• W2893717441 cites W2123424607 @default.
• W2893717441 cites W2124479692 @default.
• W2893717441 cites W2124494829 @default.
• W2893717441 cites W2125137884 @default.
• W2893717441 cites W2125800765 @default.
• W2893717441 cites W2127161084 @default.
• W2893717441 cites W2130214645 @default.
• W2893717441 cites W2136464092 @default.
• W2893717441 cites W2136527387 @default.
• W2893717441 cites W2137453609 @default.
• W2893717441 cites W2141901540 @default.
• W2893717441 cites W2146104972 @default.
• W2893717441 cites W2152851072 @default.
• W2893717441 cites W2156426990 @default.
• W2893717441 cites W2156545952 @default.
• W2893717441 cites W2158107150 @default.
• W2893717441 cites W2159269304 @default.
• W2893717441 cites W2169696276 @default.
• W2893717441 cites W2170019188 @default.
• W2893717441 cites W2175879646 @default.
• W2893717441 cites W2198063470 @default.
• W2893717441 cites W2306526634 @default.
• W2893717441 cites W2327151307 @default.
• W2893717441 cites W2350270487 @default.
• W2893717441 cites W235803734 @default.
• W2893717441 cites W2397885266 @default.
• W2893717441 cites W2419885975 @default.
• W2893717441 cites W2443895171 @default.
• W2893717441 cites W2471954354 @default.
• W2893717441 cites W2494850533 @default.
• W2893717441 cites W2500474839 @default.
• W2893717441 cites W2548303498 @default.
• W2893717441 cites W2551423252 @default.
• W2893717441 cites W2560946397 @default.
• W2893717441 cites W2569773768 @default.
• W2893717441 cites W2588882259 @default.
• W2893717441 cites W2604229156 @default.
• W2893717441 cites W2607191494 @default.
• W2893717441 cites W2607303210 @default.

• next