Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893724727> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2893724727 endingPage "125" @default.
- W2893724727 startingPage "117" @default.
- W2893724727 abstract "The plant Cassia fistula L. (Caesalpiniaceae) is traditionally used to treat heart diseases, abdominal pain and fever. The present study was aimed to investigate the toxic effects acute and sub-acute administration of ethanol extract of C. fistula fruit (CFE) in male Wistar rats.In acute toxicity, the effects of a single oral dose (1000, 3000 and 5000 mg/kg) of CFE have been determined. Animal behaviour and mortality were determined for up to 14 days. In sub-acute study, the effects of CFE in daily single oral administration at the doses of 250, 500 and 1000 mg/kg during 28 days were determined. The blood haematological and biochemical parameters, as well as the histopathological examination of the liver, heart and kidneys were studied.In acute study, a single administration of the CFE up to a dose of 5000 mg/kg did not induce mortality. Thus, the LD50 of the CFE has been estimated higher than 5000 mg/kg. In sub-acute toxicity study, administration of CFE at the doses of 250, 500 and 1000 mg/kg to rats did not induce mortality. No significant differences were found in relative organ weight, and haematological and biochemical analyses in treated groups compared to control group. No noticeable histological changes were observed in organs of CFE-treated rats compared to controls.These results have shown that oral administration of C. fistula fruit did not produce any significant toxic effect in male rats. Hence, C. fistula fruit could be regarded as a safe natural product for therapeutic use." @default.
- W2893724727 created "2018-10-05" @default.
- W2893724727 creator A5023338166 @default.
- W2893724727 creator A5081298325 @default.
- W2893724727 date "2019-04-16" @default.
- W2893724727 modified "2023-10-16" @default.
- W2893724727 title "Acute and sub-acute oral toxicity of ethanol extract of Cassia fistula fruit in male rats." @default.
- W2893724727 cites W1835101323 @default.
- W2893724727 cites W1992745272 @default.
- W2893724727 cites W2007569394 @default.
- W2893724727 cites W2010841546 @default.
- W2893724727 cites W2045105204 @default.
- W2893724727 cites W2087674046 @default.
- W2893724727 cites W2115080951 @default.
- W2893724727 cites W2137864211 @default.
- W2893724727 cites W2155853588 @default.
- W2893724727 cites W2308980451 @default.
- W2893724727 cites W2415399237 @default.
- W2893724727 cites W2498965499 @default.
- W2893724727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6448542" @default.
- W2893724727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30984576" @default.
- W2893724727 hasPublicationYear "2019" @default.
- W2893724727 type Work @default.
- W2893724727 sameAs 2893724727 @default.
- W2893724727 citedByCount "3" @default.
- W2893724727 countsByYear W28937247272020 @default.
- W2893724727 countsByYear W28937247272022 @default.
- W2893724727 crossrefType "journal-article" @default.
- W2893724727 hasAuthorship W2893724727A5023338166 @default.
- W2893724727 hasAuthorship W2893724727A5081298325 @default.
- W2893724727 hasConcept C116263406 @default.
- W2893724727 hasConcept C126322002 @default.
- W2893724727 hasConcept C142724271 @default.
- W2893724727 hasConcept C188947578 @default.
- W2893724727 hasConcept C204787440 @default.
- W2893724727 hasConcept C2775939860 @default.
- W2893724727 hasConcept C2777056448 @default.
- W2893724727 hasConcept C29730261 @default.
- W2893724727 hasConcept C42407357 @default.
- W2893724727 hasConcept C71924100 @default.
- W2893724727 hasConcept C98274493 @default.
- W2893724727 hasConceptScore W2893724727C116263406 @default.
- W2893724727 hasConceptScore W2893724727C126322002 @default.
- W2893724727 hasConceptScore W2893724727C142724271 @default.
- W2893724727 hasConceptScore W2893724727C188947578 @default.
- W2893724727 hasConceptScore W2893724727C204787440 @default.
- W2893724727 hasConceptScore W2893724727C2775939860 @default.
- W2893724727 hasConceptScore W2893724727C2777056448 @default.
- W2893724727 hasConceptScore W2893724727C29730261 @default.
- W2893724727 hasConceptScore W2893724727C42407357 @default.
- W2893724727 hasConceptScore W2893724727C71924100 @default.
- W2893724727 hasConceptScore W2893724727C98274493 @default.
- W2893724727 hasIssue "2" @default.
- W2893724727 hasLocation W28937247271 @default.
- W2893724727 hasLocation W28937247272 @default.
- W2893724727 hasOpenAccess W2893724727 @default.
- W2893724727 hasPrimaryLocation W28937247271 @default.
- W2893724727 hasRelatedWork W2402651161 @default.
- W2893724727 hasRelatedWork W2410810711 @default.
- W2893724727 hasRelatedWork W2470420247 @default.
- W2893724727 hasRelatedWork W2893724727 @default.
- W2893724727 hasRelatedWork W2912516589 @default.
- W2893724727 hasRelatedWork W30168135 @default.
- W2893724727 hasRelatedWork W3195292203 @default.
- W2893724727 hasRelatedWork W4253925169 @default.
- W2893724727 hasRelatedWork W1544217810 @default.
- W2893724727 hasRelatedWork W4225691016 @default.
- W2893724727 hasVolume "9" @default.
- W2893724727 isParatext "false" @default.
- W2893724727 isRetracted "false" @default.
- W2893724727 magId "2893724727" @default.
- W2893724727 workType "article" @default.