FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893726395> ?p ?o ?g. }

• W2893726395 endingPage "62" @default.
• W2893726395 startingPage "54" @default.
• W2893726395 abstract "Cis-3-O-p-hydroxycinnamoyl ursolic acid (HCUA), a triterpenoid compound, was purified from Elaeagnus oldhamii Maxim. This traditional medicinal plant has been used for treating rheumatoid arthritis and lung disorders as well as for its anti-inflammation and anticancer activities. This study aimed to investigate the anti-proliferative and apoptotic-inducing activities of HCUA in oral cancer cells. HCUA exhibited anti-proliferative activity in oral cancer cell lines (Ca9-22 and SAS cells), but not in normal oral fibroblasts. The inhibitory concentration of HCUA that resulted in 50% viability was 24.0 µM and 17.8 µM for Ca9-22 and SAS cells, respectively. Moreover, HCUA increased the number of cells in the sub-G1 arrest phase and apoptosis in a concentration-dependent manner in both oral cancer cell lines, but not in normal oral fibroblasts. Importantly, HCUA induced p53-mediated transcriptional regulation of pro-apoptotic proteins (Bax, Bak, Bim, Noxa, and PUMA), which are associated with mitochondrial apoptosis in oral cancer cells via the loss of mitochondrial membrane potential. HCUA triggered the production of intracellular reactive oxygen species (ROS) that was ascertained to be involved in HCUA-induced apoptosis by the ROS inhibitors YCG063 and N-acetyl-L-cysteine. As a result, HCUA had potential antitumor activity to oral cancer cells through eliciting ROS-dependent and p53-mediated mitochondrial apoptosis. Overall, HCUA could be applicable for the development of anticancer agents against human oral cancer." @default.
• W2893726395 created "2018-10-05" @default.
• W2893726395 creator A5010053551 @default.
• W2893726395 creator A5020361863 @default.
• W2893726395 creator A5032568029 @default.
• W2893726395 creator A5038058668 @default.
• W2893726395 creator A5045721425 @default.
• W2893726395 creator A5045931753 @default.
• W2893726395 creator A5051013712 @default.
• W2893726395 creator A5071469477 @default.
• W2893726395 creator A5084562736 @default.
• W2893726395 creator A5088873988 @default.
• W2893726395 date "2019-01-01" @default.
• W2893726395 modified "2023-10-14" @default.
• W2893726395 title "<i>Cis-3-O-p-</i>hydroxycinnamoyl Ursolic Acid Induced ROS-Dependent p53-Mediated Mitochondrial Apoptosis in Oral Cancer Cells" @default.
• W2893726395 cites W1913371122 @default.
• W2893726395 cites W1933981160 @default.
• W2893726395 cites W1969955892 @default.
• W2893726395 cites W1970997305 @default.
• W2893726395 cites W1973238726 @default.
• W2893726395 cites W1981815345 @default.
• W2893726395 cites W1987092520 @default.
• W2893726395 cites W1987662208 @default.
• W2893726395 cites W1988857580 @default.
• W2893726395 cites W1990717765 @default.
• W2893726395 cites W2004284414 @default.
• W2893726395 cites W2006691847 @default.
• W2893726395 cites W2008715871 @default.
• W2893726395 cites W2019682528 @default.
• W2893726395 cites W2019789751 @default.
• W2893726395 cites W2020830322 @default.
• W2893726395 cites W2024996523 @default.
• W2893726395 cites W2031322056 @default.
• W2893726395 cites W203152931 @default.
• W2893726395 cites W2036411709 @default.
• W2893726395 cites W2057839285 @default.
• W2893726395 cites W2058635721 @default.
• W2893726395 cites W2059021281 @default.
• W2893726395 cites W2063378726 @default.
• W2893726395 cites W2066789693 @default.
• W2893726395 cites W2071789148 @default.
• W2893726395 cites W2081878008 @default.
• W2893726395 cites W2085267622 @default.
• W2893726395 cites W2090362418 @default.
• W2893726395 cites W2098935972 @default.
• W2893726395 cites W2100550784 @default.
• W2893726395 cites W2101082817 @default.
• W2893726395 cites W2107276107 @default.
• W2893726395 cites W2131316342 @default.
• W2893726395 cites W2147504123 @default.
• W2893726395 cites W2159268346 @default.
• W2893726395 cites W2162766713 @default.
• W2893726395 cites W2172756222 @default.
• W2893726395 cites W2190439558 @default.
• W2893726395 cites W2285650663 @default.
• W2893726395 cites W2297663388 @default.
• W2893726395 cites W2347015734 @default.
• W2893726395 cites W2378604819 @default.
• W2893726395 cites W2406213538 @default.
• W2893726395 cites W2408239743 @default.
• W2893726395 cites W2415539887 @default.
• W2893726395 cites W2460919171 @default.
• W2893726395 cites W2479381614 @default.
• W2893726395 cites W2493573981 @default.
• W2893726395 cites W2494519712 @default.
• W2893726395 cites W2593765471 @default.
• W2893726395 cites W2602141890 @default.
• W2893726395 doi "https://doi.org/10.4062/biomolther.2017.237" @default.
• W2893726395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6319548" @default.
• W2893726395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30261716" @default.
• W2893726395 hasPublicationYear "2019" @default.
• W2893726395 type Work @default.
• W2893726395 sameAs 2893726395 @default.
• W2893726395 citedByCount "7" @default.
• W2893726395 countsByYear W28937263952019 @default.
• W2893726395 countsByYear W28937263952020 @default.
• W2893726395 countsByYear W28937263952021 @default.
• W2893726395 countsByYear W28937263952022 @default.
• W2893726395 crossrefType "journal-article" @default.
• W2893726395 hasAuthorship W2893726395A5010053551 @default.
• W2893726395 hasAuthorship W2893726395A5020361863 @default.
• W2893726395 hasAuthorship W2893726395A5032568029 @default.
• W2893726395 hasAuthorship W2893726395A5038058668 @default.
• W2893726395 hasAuthorship W2893726395A5045721425 @default.
• W2893726395 hasAuthorship W2893726395A5045931753 @default.
• W2893726395 hasAuthorship W2893726395A5051013712 @default.
• W2893726395 hasAuthorship W2893726395A5071469477 @default.
• W2893726395 hasAuthorship W2893726395A5084562736 @default.
• W2893726395 hasAuthorship W2893726395A5088873988 @default.
• W2893726395 hasBestOaLocation W28937263952 @default.
• W2893726395 hasConcept C121608353 @default.
• W2893726395 hasConcept C185592680 @default.
• W2893726395 hasConcept C190283241 @default.
• W2893726395 hasConcept C2779513101 @default.
• W2893726395 hasConcept C28859421 @default.
• W2893726395 hasConcept C48349386 @default.
• W2893726395 hasConcept C502942594 @default.
• W2893726395 hasConcept C54355233 @default.

• next