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- W2893730856 abstract "Abstract Objectives We aimed to assess the effect of selective intracoronary hypothermia on outcomes in patients with ST‐segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Background Intracoronary hypothermia, the feasibility and safety of which has been validated in humans, induced by selective trans‐coronary infusion of saline at different temperatures can reduce infarct size (IS) prior to reperfusion in animal models of STEMI. Methods Sixty STEMI patients presenting with thrombolysis in myocardial infarction (TIMI) flow grade 0/1 were randomized after coronary artery angiography. Intracoronary hypothermia was induced by selective trans‐coronary infusion of saline at 4°C to the endangered myocardium in the 30 patients. The primary endpoint, absolute IS expressed as IS/myocardium at risk (MaR), was assessed by cardiac magnetic resonance imaging at day 7 post‐PPCI in 50 patients. Clinical follow‐up was undertaken at day 30 after procedure. Results Intracoronary hypothermia was successfully performed in hypothermia group, without increase in arrhythmia or hemodynamic instability. The mean temperature reduction of 5.8 ± 1.1°C in distal coronary artery was achieved before reperfusion. Mean IS/MaR was predominantly reduced in the hypothermia group (44.85 ± 5.89% vs. 50.69 ± 10.75%, P = 0.022), especially in the anterior STEMI subgroup (46.12 ± 7.54% vs. 55.27 ± 11.175%, P = 0.023). The clinical events appeared no statistical difference between the two groups at the 30‐day follow‐up. Conclusion The statistical difference in IS/MaR by intracoronary hypothermia as adjunctive therapy to PPCI is an important observation and warrants a larger pivotal trial fully powered for efficacy." @default.
- W2893730856 created "2018-10-05" @default.
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- W2893730856 date "2018-09-28" @default.
- W2893730856 modified "2023-10-09" @default.
- W2893730856 title "A pilot clinical study of adjunctive therapy with selective intracoronary hypothermia in patients with ST‐segment elevation myocardial infarction" @default.
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- W2893730856 doi "https://doi.org/10.1002/ccd.27864" @default.
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