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• W2893732344 abstract "Recently, a newer generation of absorbable biomaterials has been developed from silk. Silk is approved by the US Food and Drug Administration, has robust mechanical features, and is biocompatible. Moreover, it offers the ability to be functionalized with bioactive compounds, making it ideal for use in new medical devices. Thus, many researchers have considered that absorbable devices made from silk may be able to overcome current limitations and could be used to meet a broader range of fixation needs. Here, we describe a novel method for the fabrication of silk fibroin (SF)–based bioabsorbable fixation systems using a centrifugal casting technique and incorporating a 3D printer. This approach allows us to create the desired geometric design for the fixation system easily. Moreover, our products demonstrated smoother surface profiles and more homogenous and dense cross-sectional architectures. Furthermore, our plates exhibited very similar mechanical properties compared with commercially used one, and our screws showed more than 70% of their initial mass after 7 weeks on the enzymatic degradation test. On in vivo analysis, we found that our devices were well-maintained in the location of initial fixation, and new bone formation was also observed around this. By these results, we suggest that the SF-based plate/screw prepared by our novel method might be used for the internal fixation of fracture sites." @default.
• W2893732344 created "2018-10-05" @default.
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• W2893732344 date "2018-10-18" @default.
• W2893732344 modified "2023-09-26" @default.
• W2893732344 title "New fabrication method of silk fibroin plate and screw based on a centrifugal casting technique" @default.
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• W2893732344 doi "https://doi.org/10.1002/term.2752" @default.
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• W2893732344 hasPublicationYear "2018" @default.
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