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• W2893733630 abstract "Congratulations to Haunschild and colleagues [1Haunschild J. Schellinger I.N. von Salisch S. et al.Granular media calcinosis in the aortic walls of patients with bicuspid and tricuspid aortic valves.Ann Thorac Surg. 2017; 103: 1178-1185Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar] for this valuable effort reported in The Annals of Thoracic Surgery. We want to point out some issues about their study. In Table 1, the mean diameters of the ascending aorta are significantly different between the tricuspid aortic valve (TAV) and bicuspid aortic valve (BAV) groups. This difference may have had an effect on the microscopic findings of each group. The existence and site of the jet flow in aortic stenosis, the higher stroke volume in aortic regurgitation, and tubular flow in aortic stenosis all have different mechanisms causing histologic changes in the aortic wall. These mechanisms were mentioned within the text. The numbers of the patients with aortic regurgitation or aortic stenosis are quite different between the TAV and BAV groups. To standardize the groups, regurgitation and stenosis subgroups should have been established within the individual TAV and BAV groups. Samples of aortic wall at the site where the jet flow hits could have given better histologic clues. Granular Media Calcinosis in the Aortic Walls of Patients With Bicuspid and Tricuspid Aortic ValvesThe Annals of Thoracic SurgeryVol. 103Issue 4PreviewBicuspid aortic valve (BAV), the most frequent congenital cardiac abnormality, is associated with a higher risk for ascending aortic aneurysms and aorta-related complications (ie, dissection and rupture). The aim of this study was to quantify granular media calcinosis (GMC) in the ascending aortic wall of patients with BAV. Full-Text PDF ReplyThe Annals of Thoracic SurgeryVol. 107Issue 2PreviewWe thank Dr Yurekli and colleagues [1] for sharing their concerns about our study [2]. It is true that the groups of patients with bicuspid aortic valves (BAVs) and tricuspid aortic valves (TAVs) differed significantly, in particular with regard to aortic diameter and valve dysfunction in our clinical “all-comers” study, “Granular Media Calcinosis in the Aortic Walls of Patients With Bicuspid and Tricuspid Aortic Valves,” of 87 consecutive surgical patients [2]. However, when subdividing the patients according to aortic diameter into three groups (<50 mm, 50 to 55 mm, >55 mm), a significantly higher level of granular media calcinosis in BAVs is still present (see Fig 5 in our paper [2]). Full-Text PDF" @default.
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• W2893733630 date "2019-02-01" @default.
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• W2893733630 title "Standardization Within Groups Is Necessary" @default.
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• W2893733630 doi "https://doi.org/10.1016/j.athoracsur.2018.07.073" @default.
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