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- W2893740802 endingPage "138" @default.
- W2893740802 startingPage "129" @default.
- W2893740802 abstract "Insulin resistance is caused by various environmental and genetic factors leading to a number of serious health issues. Due to its multifactorial origin, molecular characterization may provide better tools for its effective treatment. On molecular level, dysregulation of signaling pathway by insulin receptor substrates (IRSs) is one of the most common reasons of this disease. IRSs are regulated by >50 serine/threonine kinases, which may have positive or negative effects on insulin sensitivity. Among these serine/threonine kinases, PIM kinases have garnered much attention as they not only affect insulin sensitivity by phosphorylating IRSs directly and/or indirectly but also alter the activities of their downstream molecules like PI3K, AKT, and mTOR. In this review, interactions of PIM kinases with IRSs and their downstream proteins and their action mechanism in the regulation of insulin resistance are elaborated. Furthermore, this review offers fundamental understandings of the role of PIM kinases in this signaling pathway." @default.
- W2893740802 created "2018-10-05" @default.
- W2893740802 creator A5009159461 @default.
- W2893740802 creator A5081075360 @default.
- W2893740802 creator A5089755626 @default.
- W2893740802 creator A5090581970 @default.
- W2893740802 creator A5090815103 @default.
- W2893740802 date "2018-09-29" @default.
- W2893740802 modified "2023-09-26" @default.
- W2893740802 title "Regulation of insulin resistance and glucose metabolism by interaction of PIM kinases and insulin receptor substrates" @default.
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