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• W2893743889 abstract "The primary goal was to assess the effects of chronic sildenafil treatment over the Achilles tendons in rats.Animals were divided into two groups, control and sildenafil administration (n = 5). After 60 days, the tendons were subject to biochemical and image analysis to compare tendons between the groups: collagen I and decorin content, polarisation microscopy and birefringence analysis, and tissue zymography.The animals exposed to sildenafil presented a much less organised tendon matrix, with reduced collagen I and non-collagenous protein content and a much higher decorin content.The results observed in the animals can be characterised as tendinopathy, a condition not yet described as a sildenafil side effect." @default.
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• W2893743889 date "2018-11-01" @default.
• W2893743889 modified "2023-10-04" @default.
• W2893743889 title "Chronical treatment with sildenafil causes Achilles tendinopathy in rats" @default.
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• W2893743889 doi "https://doi.org/10.1016/j.lfs.2018.09.048" @default.
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