FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893745744> ?p ?o ?g. }

• W2893745744 abstract "Nuclear RNA interference provides a unique approach to the study of RNA-mediated transgenerational epigenetic inheritance. A paradox in the field is that expression of target loci is necessary for the initiation and maintenance of their silencing. How expression and repression are coordinated during animal development is poorly understood. To resolve this gap, we took imaging, deep-sequencing and genetic approaches towards delineating the developmental regulation and subcellular localization of RNA transcripts of two representative endogenous targets, the LTR retrotransposons Cer3 and Cer8. By examining wild-type worms and a collection of mutant strains, we found that the expression and silencing cycle of Cer3 and Cer8 is coupled with embryonic and germline development. Strikingly, endogenous targets exhibit a hallmark of nuclear enrichment of their RNA transcripts. In addition, germline and somatic repressions of Cer3 have different genetic requirements for three heterochromatin enzymes, MET-2, SET-25 and SET-32, in conjunction with the nuclear Argonaute protein HRDE-1. These results provide the first comprehensive cellular and developmental characterization of nuclear RNAi activities throughout the animal reproductive cycle." @default.
• W2893745744 created "2018-10-05" @default.
• W2893745744 creator A5014390141 @default.
• W2893745744 creator A5019985628 @default.
• W2893745744 creator A5037074936 @default.
• W2893745744 creator A5062842496 @default.
• W2893745744 date "2018-01-01" @default.
• W2893745744 modified "2023-10-05" @default.
• W2893745744 title "The spatial and temporal dynamics of nuclear RNAi-targeted retrotransposon transcripts in <i>Caenorhabditis elegans</i>" @default.
• W2893745744 cites W1846312500 @default.
• W2893745744 cites W1885681284 @default.
• W2893745744 cites W1944127002 @default.
• W2893745744 cites W1954154760 @default.
• W2893745744 cites W1964388814 @default.
• W2893745744 cites W1965532812 @default.
• W2893745744 cites W1975539651 @default.
• W2893745744 cites W1975542747 @default.
• W2893745744 cites W1976228664 @default.
• W2893745744 cites W1980907602 @default.
• W2893745744 cites W1986504960 @default.
• W2893745744 cites W1987112627 @default.
• W2893745744 cites W1993907364 @default.
• W2893745744 cites W1997412567 @default.
• W2893745744 cites W2004261465 @default.
• W2893745744 cites W2004658265 @default.
• W2893745744 cites W2013793916 @default.
• W2893745744 cites W2018249152 @default.
• W2893745744 cites W2027891004 @default.
• W2893745744 cites W2032640887 @default.
• W2893745744 cites W2037430996 @default.
• W2893745744 cites W2038720758 @default.
• W2893745744 cites W2047285578 @default.
• W2893745744 cites W2056398241 @default.
• W2893745744 cites W2059037240 @default.
• W2893745744 cites W2068878293 @default.
• W2893745744 cites W2069433314 @default.
• W2893745744 cites W2071151516 @default.
• W2893745744 cites W2080248723 @default.
• W2893745744 cites W2080406993 @default.
• W2893745744 cites W2092809432 @default.
• W2893745744 cites W2100365580 @default.
• W2893745744 cites W2102335229 @default.
• W2893745744 cites W2112785601 @default.
• W2893745744 cites W2117521691 @default.
• W2893745744 cites W2118076127 @default.
• W2893745744 cites W2120998017 @default.
• W2893745744 cites W2121895515 @default.
• W2893745744 cites W2122984483 @default.
• W2893745744 cites W2124941470 @default.
• W2893745744 cites W2124985265 @default.
• W2893745744 cites W2127244622 @default.
• W2893745744 cites W2131852558 @default.
• W2893745744 cites W2132767295 @default.
• W2893745744 cites W2140341433 @default.
• W2893745744 cites W2141507532 @default.
• W2893745744 cites W2144770187 @default.
• W2893745744 cites W2145355805 @default.
• W2893745744 cites W2146394302 @default.
• W2893745744 cites W2149869194 @default.
• W2893745744 cites W2152221266 @default.
• W2893745744 cites W2152803894 @default.
• W2893745744 cites W2154166273 @default.
• W2893745744 cites W2154222068 @default.
• W2893745744 cites W2155496026 @default.
• W2893745744 cites W2155545276 @default.
• W2893745744 cites W2155696254 @default.
• W2893745744 cites W2167279371 @default.
• W2893745744 cites W2170624303 @default.
• W2893745744 cites W2234803937 @default.
• W2893745744 cites W2512439797 @default.
• W2893745744 cites W2588395757 @default.
• W2893745744 cites W2588586530 @default.
• W2893745744 cites W2594424912 @default.
• W2893745744 cites W2601782473 @default.
• W2893745744 cites W2606638040 @default.
• W2893745744 cites W2619990190 @default.
• W2893745744 cites W2620999934 @default.
• W2893745744 cites W2736224128 @default.
• W2893745744 cites W2744781424 @default.
• W2893745744 cites W2790591579 @default.
• W2893745744 cites W2804348858 @default.
• W2893745744 cites W2804476437 @default.
• W2893745744 cites W2949552515 @default.
• W2893745744 cites W4241031272 @default.
• W2893745744 cites W4256266823 @default.
• W2893745744 cites W889211313 @default.
• W2893745744 cites W919162665 @default.
• W2893745744 doi "https://doi.org/10.1242/dev.167346" @default.
• W2893745744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6215403" @default.
• W2893745744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254142" @default.
• W2893745744 hasPublicationYear "2018" @default.
• W2893745744 type Work @default.
• W2893745744 sameAs 2893745744 @default.
• W2893745744 citedByCount "11" @default.
• W2893745744 countsByYear W28937457442018 @default.
• W2893745744 countsByYear W28937457442019 @default.
• W2893745744 countsByYear W28937457442020 @default.
• W2893745744 countsByYear W28937457442021 @default.
• W2893745744 countsByYear W28937457442022 @default.
• W2893745744 countsByYear W28937457442023 @default.

• next