FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893752015> ?p ?o ?g. }

• W2893752015 abstract "MicroRNA (miRNA/miR)-124 is a miRNA, which exerts tumor suppressive effects but is frequently absent in tumors. Although it has been validated to target oncogenic genes such as signal transducer and activator of transcription 3, forkhead box Q1, and Slug, the mechanistic link between miR‑124 and potential target genes that contribute to tumor progression, is yet to be investigated. IQ motif containing GTPase activating protein 1 (IQGAP1) is a scaffold protein that participates in protein‑protein interactions and integrating diverse signaling pathways. Previous studies suggest that overexpression of IQGAP1 enhances activity of mitogen activated protein kinase 1 and β‑catenin signaling cascades to facilitate tumor progression. The present study aimed to identify the regulative link between miR‑124 and IQGAP1 in colorectal cancer (CRC). It was demonstrated that IQGAP1 was aberrantly overexpressed in CRC tissues and cell lines. Knockdown of IQGPA1 by introducing short hairpin‑IQGAP1 lentivirus inhibited CRC cell growth and colony formation ability, and simultaneously suppressed phosphorylation of extracellular signal‑regulated kinase (ERK)1/2 and β‑catenin expression. Furthermore, it was demonstrated that miR‑124 was silenced in CRC. Restoration of miR‑124 in CRC cells impeded cell growth and colony formation ability. The direct binding of miR‑124 to the 3'untranslated region of IQGAP1 mRNA was confirmed using a luciferase reporter gene assay. Importantly, downregulation of IQGAP1 expression was observed in miR‑124‑restoration cells with simultaneous reduction of phosphorylated‑ERK1/2 and β‑catenin. In conclusion, the present study describes a potential mechanism underlying the miR‑124/IQGAP1 link in CRC progression. Silencing of miR‑124 may depress IQGAP1 expression, leading to increased activity of ERK1/2 and β‑catenin signaling." @default.
• W2893752015 created "2018-10-05" @default.
• W2893752015 creator A5003257167 @default.
• W2893752015 creator A5033210778 @default.
• W2893752015 creator A5055875257 @default.
• W2893752015 creator A5059820497 @default.
• W2893752015 creator A5071773009 @default.
• W2893752015 creator A5085095645 @default.
• W2893752015 date "2018-09-27" @default.
• W2893752015 modified "2023-09-25" @default.
• W2893752015 title "miR‑124 inhibits cell growth through targeting IQGAP1 in colorectal cancer" @default.
• W2893752015 cites W1648301895 @default.
• W2893752015 cites W1979053361 @default.
• W2893752015 cites W1985643113 @default.
• W2893752015 cites W1989571888 @default.
• W2893752015 cites W2000214286 @default.
• W2893752015 cites W2001433378 @default.
• W2893752015 cites W2003231677 @default.
• W2893752015 cites W2011856953 @default.
• W2893752015 cites W2028816685 @default.
• W2893752015 cites W2046851763 @default.
• W2893752015 cites W2052550299 @default.
• W2893752015 cites W2068361347 @default.
• W2893752015 cites W2074671154 @default.
• W2893752015 cites W2078948671 @default.
• W2893752015 cites W2079078062 @default.
• W2893752015 cites W2085982536 @default.
• W2893752015 cites W2094584332 @default.
• W2893752015 cites W2099277978 @default.
• W2893752015 cites W2107277218 @default.
• W2893752015 cites W2108598050 @default.
• W2893752015 cites W2112053464 @default.
• W2893752015 cites W2124102897 @default.
• W2893752015 cites W2127594372 @default.
• W2893752015 cites W2131298313 @default.
• W2893752015 cites W2139056019 @default.
• W2893752015 cites W2145920293 @default.
• W2893752015 cites W2158734599 @default.
• W2893752015 cites W2164364079 @default.
• W2893752015 cites W2252689760 @default.
• W2893752015 cites W2339552413 @default.
• W2893752015 cites W2345395486 @default.
• W2893752015 cites W2561201516 @default.
• W2893752015 cites W2751264682 @default.
• W2893752015 cites W2774123716 @default.
• W2893752015 cites W2790048064 @default.
• W2893752015 cites W2792134484 @default.
• W2893752015 cites W2793471550 @default.
• W2893752015 cites W2795095161 @default.
• W2893752015 cites W2796117568 @default.
• W2893752015 cites W4242940699 @default.
• W2893752015 doi "https://doi.org/10.3892/mmr.2018.9518" @default.
• W2893752015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30272357" @default.
• W2893752015 hasPublicationYear "2018" @default.
• W2893752015 type Work @default.
• W2893752015 sameAs 2893752015 @default.
• W2893752015 citedByCount "8" @default.
• W2893752015 countsByYear W28937520152020 @default.
• W2893752015 countsByYear W28937520152021 @default.
• W2893752015 countsByYear W28937520152022 @default.
• W2893752015 countsByYear W28937520152023 @default.
• W2893752015 crossrefType "journal-article" @default.
• W2893752015 hasAuthorship W2893752015A5003257167 @default.
• W2893752015 hasAuthorship W2893752015A5033210778 @default.
• W2893752015 hasAuthorship W2893752015A5055875257 @default.
• W2893752015 hasAuthorship W2893752015A5059820497 @default.
• W2893752015 hasAuthorship W2893752015A5071773009 @default.
• W2893752015 hasAuthorship W2893752015A5085095645 @default.
• W2893752015 hasBestOaLocation W28937520151 @default.
• W2893752015 hasConcept C104317684 @default.
• W2893752015 hasConcept C145059251 @default.
• W2893752015 hasConcept C1491633281 @default.
• W2893752015 hasConcept C173396325 @default.
• W2893752015 hasConcept C184235292 @default.
• W2893752015 hasConcept C2779560292 @default.
• W2893752015 hasConcept C2781018059 @default.
• W2893752015 hasConcept C29537977 @default.
• W2893752015 hasConcept C502942594 @default.
• W2893752015 hasConcept C53645450 @default.
• W2893752015 hasConcept C54355233 @default.
• W2893752015 hasConcept C57074206 @default.
• W2893752015 hasConcept C62112901 @default.
• W2893752015 hasConcept C62478195 @default.
• W2893752015 hasConcept C81885089 @default.
• W2893752015 hasConcept C86803240 @default.
• W2893752015 hasConcept C95444343 @default.
• W2893752015 hasConceptScore W2893752015C104317684 @default.
• W2893752015 hasConceptScore W2893752015C145059251 @default.
• W2893752015 hasConceptScore W2893752015C1491633281 @default.
• W2893752015 hasConceptScore W2893752015C173396325 @default.
• W2893752015 hasConceptScore W2893752015C184235292 @default.
• W2893752015 hasConceptScore W2893752015C2779560292 @default.
• W2893752015 hasConceptScore W2893752015C2781018059 @default.
• W2893752015 hasConceptScore W2893752015C29537977 @default.
• W2893752015 hasConceptScore W2893752015C502942594 @default.
• W2893752015 hasConceptScore W2893752015C53645450 @default.
• W2893752015 hasConceptScore W2893752015C54355233 @default.
• W2893752015 hasConceptScore W2893752015C57074206 @default.
• W2893752015 hasConceptScore W2893752015C62112901 @default.
• W2893752015 hasConceptScore W2893752015C62478195 @default.

• next