Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893755534> ?p ?o ?g. }
- W2893755534 abstract "The present study investigated the underlying molecular mechanism by which Buthus martensii Karsch chlorotoxin (BmK CT) inhibits the invasion and metastasis of glioma cells and the possibility of 131I‑labeled BmK CT (131I‑BmK CT) as a novel targeted agent for the treatment of glioma. The impact of BmK CT with and without 131I radiolabeling on the invasion and metastasis of glioma cells in vitro was studied. Cell viability was assessed using Cell Counting Kit‑8 and plate colony formation assays in order to confirm the cytotoxicity of BmK CT and 131I‑BmK CT at different concentrations. Transwell invasion and wound‑healing assays were conducted in order to investigate the inhibitory effects BmK CT and 131I‑BmK CT on cell migration and invasion. Furthermore, western blotting, ELISA immunofluorescence and a gelatin zymography assay were performed to evaluate changes in the protein expression levels of glioma cells following treatment with BmK CT or 131I‑BmK CT. The results indicated that BmK CT inhibits the invasion and metastasis of glioma cells via regulation of tissue inhibitor of metalloproteinase‑2 expression and that 131I‑BmK CT has the potential to be a novel targeted therapeutic drug for glioma." @default.
- W2893755534 created "2018-10-05" @default.
- W2893755534 creator A5010873439 @default.
- W2893755534 creator A5029803643 @default.
- W2893755534 creator A5031608589 @default.
- W2893755534 creator A5034605417 @default.
- W2893755534 creator A5053368560 @default.
- W2893755534 creator A5056684346 @default.
- W2893755534 creator A5076845933 @default.
- W2893755534 creator A5083284087 @default.
- W2893755534 creator A5088821817 @default.
- W2893755534 date "2018-10-01" @default.
- W2893755534 modified "2023-10-18" @default.
- W2893755534 title "Anti-metastatic effect of 131I-labeled Buthus�martensii Karsch chlorotoxin in gliomas" @default.
- W2893755534 cites W1527463407 @default.
- W2893755534 cites W1539840728 @default.
- W2893755534 cites W1949259756 @default.
- W2893755534 cites W1970353818 @default.
- W2893755534 cites W1976096075 @default.
- W2893755534 cites W1978818883 @default.
- W2893755534 cites W1984483611 @default.
- W2893755534 cites W1992418109 @default.
- W2893755534 cites W1995806069 @default.
- W2893755534 cites W2000582871 @default.
- W2893755534 cites W2005334224 @default.
- W2893755534 cites W2013692234 @default.
- W2893755534 cites W2022233074 @default.
- W2893755534 cites W2028513366 @default.
- W2893755534 cites W2056753605 @default.
- W2893755534 cites W2072058809 @default.
- W2893755534 cites W2072619059 @default.
- W2893755534 cites W2080686007 @default.
- W2893755534 cites W2081772414 @default.
- W2893755534 cites W2082892212 @default.
- W2893755534 cites W2087200744 @default.
- W2893755534 cites W2105853795 @default.
- W2893755534 cites W2108272048 @default.
- W2893755534 cites W2110685305 @default.
- W2893755534 cites W2110721051 @default.
- W2893755534 cites W2111662374 @default.
- W2893755534 cites W2112027306 @default.
- W2893755534 cites W2128049766 @default.
- W2893755534 cites W2128409695 @default.
- W2893755534 cites W2129353670 @default.
- W2893755534 cites W2165205961 @default.
- W2893755534 cites W2167780449 @default.
- W2893755534 cites W2204053148 @default.
- W2893755534 cites W2239787163 @default.
- W2893755534 cites W2398245525 @default.
- W2893755534 cites W2415544269 @default.
- W2893755534 cites W2751623688 @default.
- W2893755534 cites W2768067772 @default.
- W2893755534 cites W2802492825 @default.
- W2893755534 cites W2314558962 @default.
- W2893755534 doi "https://doi.org/10.3892/ijmm.2018.3905" @default.
- W2893755534 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6202110" @default.
- W2893755534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30272348" @default.
- W2893755534 hasPublicationYear "2018" @default.
- W2893755534 type Work @default.
- W2893755534 sameAs 2893755534 @default.
- W2893755534 citedByCount "3" @default.
- W2893755534 countsByYear W28937555342022 @default.
- W2893755534 countsByYear W28937555342023 @default.
- W2893755534 crossrefType "journal-article" @default.
- W2893755534 hasAuthorship W2893755534A5010873439 @default.
- W2893755534 hasAuthorship W2893755534A5029803643 @default.
- W2893755534 hasAuthorship W2893755534A5031608589 @default.
- W2893755534 hasAuthorship W2893755534A5034605417 @default.
- W2893755534 hasAuthorship W2893755534A5053368560 @default.
- W2893755534 hasAuthorship W2893755534A5056684346 @default.
- W2893755534 hasAuthorship W2893755534A5076845933 @default.
- W2893755534 hasAuthorship W2893755534A5083284087 @default.
- W2893755534 hasAuthorship W2893755534A5088821817 @default.
- W2893755534 hasBestOaLocation W28937555341 @default.
- W2893755534 hasConcept C104317684 @default.
- W2893755534 hasConcept C121608353 @default.
- W2893755534 hasConcept C142724271 @default.
- W2893755534 hasConcept C1491633281 @default.
- W2893755534 hasConcept C153911025 @default.
- W2893755534 hasConcept C185592680 @default.
- W2893755534 hasConcept C2778227246 @default.
- W2893755534 hasConcept C2779013556 @default.
- W2893755534 hasConcept C2780783641 @default.
- W2893755534 hasConcept C2781018059 @default.
- W2893755534 hasConcept C29537977 @default.
- W2893755534 hasConcept C502942594 @default.
- W2893755534 hasConcept C53227056 @default.
- W2893755534 hasConcept C54355233 @default.
- W2893755534 hasConcept C55493867 @default.
- W2893755534 hasConcept C67082663 @default.
- W2893755534 hasConcept C71924100 @default.
- W2893755534 hasConcept C85265743 @default.
- W2893755534 hasConcept C86803240 @default.
- W2893755534 hasConceptScore W2893755534C104317684 @default.
- W2893755534 hasConceptScore W2893755534C121608353 @default.
- W2893755534 hasConceptScore W2893755534C142724271 @default.
- W2893755534 hasConceptScore W2893755534C1491633281 @default.
- W2893755534 hasConceptScore W2893755534C153911025 @default.
- W2893755534 hasConceptScore W2893755534C185592680 @default.
- W2893755534 hasConceptScore W2893755534C2778227246 @default.