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- W2893759734 endingPage "1800054" @default.
- W2893759734 startingPage "1800054" @default.
- W2893759734 abstract "Cholesterol intestinal absorption differs markedly from that of plant sterols; whereas the cholesterol absorption rate is high (30–60%) for total plant sterols it is low (2–3%). Non-absorbed sterols reach the colon, where the microbiota interacts with them. Non-absorbed cholesterol biotransformation has been widely studied by in vitro fermentation assays using gut microbiota from human feces and pure cultures of enteric microorganisms. A great variety of sterols and its metabolites have been detected, which allows establishing two pathways for cholesterol microbial degradation to coprostanol. However, biotransformation studies of plant sterols are scarce and its microbial transformation pathway remains to be fully clarified. Furthermore, the sterol contents in feces are highly variable among individuals, due to specific microbiota and especially dietary factors. However, no standardized methodology has been developed for sterols and their metabolites determination in feces. Studies on sterol excretion values, microbial transformation, and sterol determination methodology have been reviewed. Given that cholesterol metabolites can contribute to the development of colon cancer and that information about plant sterols biotransformation is scarce, this review contributes to improve the knowledge of the sterol implication in the gut microbiota and of PS impact in the colonic microbiota metabolization of cholesterol. Practical Applications: It has been suggested that the metabolites produced during the biotransformation of cholesterol have pro-carcinogenic activity within colon. In addition, it has been indicated that the intake of high doses of plant sterols can attenuate or decrease this biotransformation. However, it is still unknown if the microbial metabolites of plant sterols have the same effect as those of animal origin. In order to shed light on the aforementioned aspects, all the information about the dietary sterols biotransformation and their impact on gut microbiota have been compiled. In addition, the sterols contents in feces and their methodologic analysis have also been reviewed. This review offers a broad view on the interaction between dietary sterols and gut microbiota, which can help to the better understand the relationship between microbiota and sterols for future research studies. This review presents the impact of dietary sterol on gut microbiota and microbial transformation of dietary sterols." @default.
- W2893759734 created "2018-10-05" @default.
- W2893759734 creator A5005874875 @default.
- W2893759734 creator A5019568698 @default.
- W2893759734 creator A5026014124 @default.
- W2893759734 date "2018-10-31" @default.
- W2893759734 modified "2023-10-18" @default.
- W2893759734 title "Relationship Between Dietary Sterols and Gut Microbiota: A Review" @default.
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