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• W2893771854 abstract "BACKGROUND:The aim of this study was to determine whether senescence in renal glomeruli is involved in lupus nephritis (LN); the expression of senescence-associated β-galactosidase (SA-β-Gal) and its association with glomerular lesions were investigated in a mouse model of LN. MATERIAL AND METHODS:Eighteen MRL/lpr mice with severe proteinuria were randomly divided into 2 equal groups and intraperitoneally injected with dexamethasone (DEX) or saline; 4 age-matched mice with mild proteinuria served as controls. Serum creatinine and urinary protein levels were analyzed, and kidney histological changes were observed by periodic acid–Schiff and Sirius Red staining. SA-β-Gal was detected via histochemistry. Glomerular expression of collagen IV, α-SMA, and nephrin was analyzed by immunohistochemistry, and glomerular complement C3 deposition was tested by immunofluorescence. The relationships between SA-β-Gal expression and renal function or glomerular lesion markers were determined by Spearman’s correlation analysis. RESULTS:Mice with severe proteinuria exhibited glomerular segmental sclerosis and endothelial cell proliferation. DEX administration suppressed these lesions but had no significant effect on 24-hour urinary protein levels. The elevated glomerular expression of SA-β-Gal in proteinuric mice was attenuated by DEX treatment. In addition, DEX treatment markedly downregulated glomerular C3 deposition and collagen IV and α-SMA expression, while significantly increasing nephrin expression. Furthermore, SA-β-Gal expression was positively correlated with urinary protein levels and expression of α-SMA. CONCLUSIONS:Accelerated senescence of glomerular cells may contribute to glomerular injury in LN." @default.
• W2893771854 created "2018-10-05" @default.
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• W2893771854 date "2018-09-28" @default.
• W2893771854 modified "2023-09-26" @default.
• W2893771854 title "Accelerated Glomerular Cell Senescence in Experimental Lupus Nephritis" @default.
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• W2893771854 doi "https://doi.org/10.12659/msm.909353" @default.
• W2893771854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6180956" @default.
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