Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893774910> ?p ?o ?g. }
- W2893774910 endingPage "352" @default.
- W2893774910 startingPage "344" @default.
- W2893774910 abstract "Unsatisfactory therapeutic effects of currently used antidepressants force to search for new pharmacological treatment strategies. Recent research points to the relationship between depressive disorders and the adenosinergic system. Therefore, the main goal of our studies was to evaluate the effects of DMPX (3 mg/kg, i.p.), which possesses selectivity for adenosine A2A receptors versus A1 receptors, on the activity of imipramine (15 mg/kg, i.p.), escitalopram (2.5 mg/kg, i.p.), and reboxetine (2 mg/kg, i.p.) given in subtherapeutic doses. The studies carried out using the forced swim and tail suspension tests in mice showed that DMPX at a dose of 6 and 12 mg/kg exerts antidepressant-like effect and does not affect the locomotor activity. Co-administration of DMPX at a dose of 3 mg/kg with the studied antidepressant drugs caused the reduction of immobility time in both behavioral tests. The observed effect was not associated with an increase in the locomotor activity. To evaluate whether the observed effects were due to a pharmacokinetic/pharmacodynamic interaction, the levels of the antidepressants in blood and brain were measured using high-performance liquid chromatography. It can be assumed that the interaction between DMPX and imipramine was exclusively pharmacodynamic in nature, whereas an increased antidepressant activity of escitalopram and reboxetine was at least partly related to its pharmacokinetic interaction with DMPX." @default.
- W2893774910 created "2018-10-05" @default.
- W2893774910 creator A5019754051 @default.
- W2893774910 creator A5021937022 @default.
- W2893774910 creator A5033862921 @default.
- W2893774910 creator A5034537296 @default.
- W2893774910 creator A5036187783 @default.
- W2893774910 creator A5051410610 @default.
- W2893774910 creator A5055974568 @default.
- W2893774910 creator A5060127403 @default.
- W2893774910 creator A5068032321 @default.
- W2893774910 creator A5070490450 @default.
- W2893774910 creator A5081903016 @default.
- W2893774910 date "2018-09-28" @default.
- W2893774910 modified "2023-10-16" @default.
- W2893774910 title "Antidepressant-Like Activity of Typical Antidepressant Drugs in the Forced Swim Test and Tail Suspension Test in Mice Is Augmented by DMPX, an Adenosine A2A Receptor Antagonist" @default.
- W2893774910 cites W1044910230 @default.
- W2893774910 cites W11021844 @default.
- W2893774910 cites W1535611266 @default.
- W2893774910 cites W1563640261 @default.
- W2893774910 cites W1576503935 @default.
- W2893774910 cites W1591120748 @default.
- W2893774910 cites W1597889448 @default.
- W2893774910 cites W1604949247 @default.
- W2893774910 cites W1753727899 @default.
- W2893774910 cites W1913276139 @default.
- W2893774910 cites W1965943749 @default.
- W2893774910 cites W1969903608 @default.
- W2893774910 cites W1974463013 @default.
- W2893774910 cites W1977611961 @default.
- W2893774910 cites W1978119108 @default.
- W2893774910 cites W1979058616 @default.
- W2893774910 cites W1979406691 @default.
- W2893774910 cites W1981213877 @default.
- W2893774910 cites W1981491361 @default.
- W2893774910 cites W1984523180 @default.
- W2893774910 cites W1987680496 @default.
- W2893774910 cites W1989825133 @default.
- W2893774910 cites W1991863073 @default.
- W2893774910 cites W1993761825 @default.
- W2893774910 cites W1996502991 @default.
- W2893774910 cites W2003117890 @default.
- W2893774910 cites W2005231219 @default.
- W2893774910 cites W2005244872 @default.
- W2893774910 cites W2005594217 @default.
- W2893774910 cites W2007636259 @default.
- W2893774910 cites W2007711698 @default.
- W2893774910 cites W2008306831 @default.
- W2893774910 cites W2014175065 @default.
- W2893774910 cites W2015252734 @default.
- W2893774910 cites W2015623933 @default.
- W2893774910 cites W2018490234 @default.
- W2893774910 cites W2019115458 @default.
- W2893774910 cites W2019348310 @default.
- W2893774910 cites W2022967514 @default.
- W2893774910 cites W2024469932 @default.
- W2893774910 cites W2032609908 @default.
- W2893774910 cites W2040227196 @default.
- W2893774910 cites W2044074327 @default.
- W2893774910 cites W2048060693 @default.
- W2893774910 cites W2048664644 @default.
- W2893774910 cites W2052099657 @default.
- W2893774910 cites W2053642263 @default.
- W2893774910 cites W2053650795 @default.
- W2893774910 cites W2055502565 @default.
- W2893774910 cites W2056849709 @default.
- W2893774910 cites W2057887105 @default.
- W2893774910 cites W2059139697 @default.
- W2893774910 cites W2064261539 @default.
- W2893774910 cites W2068780263 @default.
- W2893774910 cites W2070803135 @default.
- W2893774910 cites W2073216156 @default.
- W2893774910 cites W2073561633 @default.
- W2893774910 cites W2079531713 @default.
- W2893774910 cites W2081196843 @default.
- W2893774910 cites W2084663298 @default.
- W2893774910 cites W2087778197 @default.
- W2893774910 cites W2087881873 @default.
- W2893774910 cites W2088525880 @default.
- W2893774910 cites W2091627651 @default.
- W2893774910 cites W2092300550 @default.
- W2893774910 cites W2094888594 @default.
- W2893774910 cites W2095352917 @default.
- W2893774910 cites W2106861254 @default.
- W2893774910 cites W2111329465 @default.
- W2893774910 cites W2112334970 @default.
- W2893774910 cites W2113524447 @default.
- W2893774910 cites W2135578299 @default.
- W2893774910 cites W2136306454 @default.
- W2893774910 cites W2136717001 @default.
- W2893774910 cites W2139817708 @default.
- W2893774910 cites W2155964805 @default.
- W2893774910 cites W2175840817 @default.
- W2893774910 cites W2197078876 @default.
- W2893774910 cites W2292203357 @default.
- W2893774910 cites W2343114247 @default.
- W2893774910 cites W2407532894 @default.
- W2893774910 cites W2409402041 @default.