FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893778088> ?p ?o ?g. }

• W2893778088 endingPage "116" @default.
• W2893778088 startingPage "105" @default.
• W2893778088 abstract "Magnetic particles can enrich desired cell populations to aid in understanding cell-type functions and mechanisms, diagnosis, and therapy. As cells are heterogeneous in ligand type, location, expression, and density, careful consideration of magnetic particle design for positive isolation is necessary. Antigen-specific immune cells have low frequencies, which has made studying, identifying, and utilizing these cells for therapy a challenge. Here we demonstrate the importance of magnetic particle design based on the biology of T cells. We create magnetic particles which recognize rare antigen-specific T cells and quantitatively investigate important particle properties including size, concentration, ligand density, and ligand choice in enriching these rare cells. We observe competing optima among particle parameters, with 300 nm particles functionalized with a high density of antigen-specific ligand achieving the highest enrichment and recovery of target cells. In enriching and then activating an endogenous response, 300 nm aAPCs generate nearly 65% antigen-specific T cells with at least 450-fold expansion from endogenous precursors and a 5-fold increase in numbers of antigen-specific cells after only seven days. This systematic study of particle properties in magnetic enrichment provides a case study for the engineering design principles of particles for the isolation of rare cells through biological ligands." @default.
• W2893778088 created "2018-10-05" @default.
• W2893778088 creator A5017107814 @default.
• W2893778088 creator A5019928990 @default.
• W2893778088 creator A5058493443 @default.
• W2893778088 creator A5061137097 @default.
• W2893778088 creator A5066090673 @default.
• W2893778088 creator A5069988863 @default.
• W2893778088 date "2018-12-01" @default.
• W2893778088 modified "2023-10-17" @default.
• W2893778088 title "Efficient magnetic enrichment of antigen-specific T cells by engineering particle properties" @default.
• W2893778088 cites W1488545150 @default.
• W2893778088 cites W1575215698 @default.
• W2893778088 cites W1943771969 @default.
• W2893778088 cites W1953531402 @default.
• W2893778088 cites W1965958391 @default.
• W2893778088 cites W1967025753 @default.
• W2893778088 cites W1981226457 @default.
• W2893778088 cites W1983412131 @default.
• W2893778088 cites W1989273697 @default.
• W2893778088 cites W1996139192 @default.
• W2893778088 cites W2003529295 @default.
• W2893778088 cites W2031386013 @default.
• W2893778088 cites W2043904711 @default.
• W2893778088 cites W2053740579 @default.
• W2893778088 cites W2054613427 @default.
• W2893778088 cites W2066930665 @default.
• W2893778088 cites W2077521424 @default.
• W2893778088 cites W2082990285 @default.
• W2893778088 cites W2105445500 @default.
• W2893778088 cites W2107026736 @default.
• W2893778088 cites W2116591434 @default.
• W2893778088 cites W2126500343 @default.
• W2893778088 cites W2129676200 @default.
• W2893778088 cites W2132866254 @default.
• W2893778088 cites W2144195944 @default.
• W2893778088 cites W2144967224 @default.
• W2893778088 cites W2148596794 @default.
• W2893778088 cites W2151497263 @default.
• W2893778088 cites W2162457545 @default.
• W2893778088 cites W2171083652 @default.
• W2893778088 cites W2344584996 @default.
• W2893778088 cites W2431286612 @default.
• W2893778088 cites W2559953355 @default.
• W2893778088 cites W2596914017 @default.
• W2893778088 cites W2606004721 @default.
• W2893778088 cites W2761480797 @default.
• W2893778088 cites W2788892668 @default.
• W2893778088 cites W2799731306 @default.
• W2893778088 doi "https://doi.org/10.1016/j.biomaterials.2018.09.029" @default.
• W2893778088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6284398" @default.
• W2893778088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30312851" @default.
• W2893778088 hasPublicationYear "2018" @default.
• W2893778088 type Work @default.
• W2893778088 sameAs 2893778088 @default.
• W2893778088 citedByCount "18" @default.
• W2893778088 countsByYear W28937780882018 @default.
• W2893778088 countsByYear W28937780882019 @default.
• W2893778088 countsByYear W28937780882020 @default.
• W2893778088 countsByYear W28937780882021 @default.
• W2893778088 countsByYear W28937780882022 @default.
• W2893778088 countsByYear W28937780882023 @default.
• W2893778088 crossrefType "journal-article" @default.
• W2893778088 hasAuthorship W2893778088A5017107814 @default.
• W2893778088 hasAuthorship W2893778088A5019928990 @default.
• W2893778088 hasAuthorship W2893778088A5058493443 @default.
• W2893778088 hasAuthorship W2893778088A5061137097 @default.
• W2893778088 hasAuthorship W2893778088A5066090673 @default.
• W2893778088 hasAuthorship W2893778088A5069988863 @default.
• W2893778088 hasBestOaLocation W28937780882 @default.
• W2893778088 hasConcept C116569031 @default.
• W2893778088 hasConcept C12554922 @default.
• W2893778088 hasConcept C147483822 @default.
• W2893778088 hasConcept C155672457 @default.
• W2893778088 hasConcept C170493617 @default.
• W2893778088 hasConcept C171250308 @default.
• W2893778088 hasConcept C185592680 @default.
• W2893778088 hasConcept C18903297 @default.
• W2893778088 hasConcept C192562407 @default.
• W2893778088 hasConcept C203014093 @default.
• W2893778088 hasConcept C2778517922 @default.
• W2893778088 hasConcept C55493867 @default.
• W2893778088 hasConcept C86803240 @default.
• W2893778088 hasConcept C87023908 @default.
• W2893778088 hasConcept C8891405 @default.
• W2893778088 hasConcept C95444343 @default.
• W2893778088 hasConceptScore W2893778088C116569031 @default.
• W2893778088 hasConceptScore W2893778088C12554922 @default.
• W2893778088 hasConceptScore W2893778088C147483822 @default.
• W2893778088 hasConceptScore W2893778088C155672457 @default.
• W2893778088 hasConceptScore W2893778088C170493617 @default.
• W2893778088 hasConceptScore W2893778088C171250308 @default.
• W2893778088 hasConceptScore W2893778088C185592680 @default.
• W2893778088 hasConceptScore W2893778088C18903297 @default.
• W2893778088 hasConceptScore W2893778088C192562407 @default.
• W2893778088 hasConceptScore W2893778088C203014093 @default.
• W2893778088 hasConceptScore W2893778088C2778517922 @default.
• W2893778088 hasConceptScore W2893778088C55493867 @default.

• next