FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893787493> ?p ?o ?g. }

• W2893787493 abstract "A robust cell factory that can tolerate combined inhibitory lignocellulosic compounds is essential for the cost-effective lignocellulose-based production of second-generation bioethanol and other bulk chemicals. Following high-throughput phenotyping of a yeast genomic overexpression library, we identified a Saccharomyces cerevisiae mutant (denoted AFb.01) with improved growth and fermentation performance under combined toxicity of acetic acid and furfural. AFb.01 carries overexpression of TRX1, which encodes for thioredoxin, a cellular redox machinery. Through comparative proteomics and metabolomics, the resulting cell-wide changes in the mutant were elucidated and these primarily target on the maintenance of energy and redox homeostasis and the minimization of stress-induced cell damages. In particular, the upregulation of the stress-response proteins Hsp26p and Fmp16p conferred tolerance of AFb.01 against protein denaturation and DNA damage. Moreover, increased levels of protectant metabolites such as trehalose, fatty acids, GABA and putrescine provided additional defense mechanisms for the mutant against oxidative and redox stresses. Future studies will concentrate on targeted genetic engineering to validate these mechanisms as well as to support the creation of more robust yeast strains, applicable for industrial, cost-competitive biorefinery production." @default.
• W2893787493 created "2018-10-05" @default.
• W2893787493 creator A5000176173 @default.
• W2893787493 creator A5003739680 @default.
• W2893787493 creator A5009144438 @default.
• W2893787493 creator A5024052846 @default.
• W2893787493 creator A5056252333 @default.
• W2893787493 date "2018-09-25" @default.
• W2893787493 modified "2023-10-16" @default.
• W2893787493 title "Elucidating cellular mechanisms of Saccharomyces cerevisiae tolerant to combined lignocellulosic-derived inhibitors using high-throughput phenotyping and multiomics analyses" @default.
• W2893787493 cites W1101193849 @default.
• W2893787493 cites W1505743758 @default.
• W2893787493 cites W1976873232 @default.
• W2893787493 cites W1977523943 @default.
• W2893787493 cites W1988079922 @default.
• W2893787493 cites W2015845020 @default.
• W2893787493 cites W2019491797 @default.
• W2893787493 cites W2039686221 @default.
• W2893787493 cites W2058918320 @default.
• W2893787493 cites W2063610495 @default.
• W2893787493 cites W2066253252 @default.
• W2893787493 cites W2072336914 @default.
• W2893787493 cites W2073523147 @default.
• W2893787493 cites W2083956198 @default.
• W2893787493 cites W2086582048 @default.
• W2893787493 cites W2093768752 @default.
• W2893787493 cites W2100170860 @default.
• W2893787493 cites W2102436900 @default.
• W2893787493 cites W2118555345 @default.
• W2893787493 cites W2131223372 @default.
• W2893787493 cites W2140485535 @default.
• W2893787493 cites W2148179602 @default.
• W2893787493 cites W2158416695 @default.
• W2893787493 cites W2185673600 @default.
• W2893787493 cites W2233790635 @default.
• W2893787493 cites W2270628611 @default.
• W2893787493 cites W2340720832 @default.
• W2893787493 cites W2499956173 @default.
• W2893787493 cites W2522292752 @default.
• W2893787493 cites W2560112683 @default.
• W2893787493 cites W2588053842 @default.
• W2893787493 cites W2765294969 @default.
• W2893787493 doi "https://doi.org/10.1093/femsyr/foy106" @default.
• W2893787493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30256930" @default.
• W2893787493 hasPublicationYear "2018" @default.
• W2893787493 type Work @default.
• W2893787493 sameAs 2893787493 @default.
• W2893787493 citedByCount "31" @default.
• W2893787493 countsByYear W28937874932018 @default.
• W2893787493 countsByYear W28937874932019 @default.
• W2893787493 countsByYear W28937874932020 @default.
• W2893787493 countsByYear W28937874932021 @default.
• W2893787493 countsByYear W28937874932022 @default.
• W2893787493 countsByYear W28937874932023 @default.
• W2893787493 crossrefType "journal-article" @default.
• W2893787493 hasAuthorship W2893787493A5000176173 @default.
• W2893787493 hasAuthorship W2893787493A5003739680 @default.
• W2893787493 hasAuthorship W2893787493A5009144438 @default.
• W2893787493 hasAuthorship W2893787493A5024052846 @default.
• W2893787493 hasAuthorship W2893787493A5056252333 @default.
• W2893787493 hasBestOaLocation W28937874931 @default.
• W2893787493 hasConcept C100544194 @default.
• W2893787493 hasConcept C181199279 @default.
• W2893787493 hasConcept C21565614 @default.
• W2893787493 hasConcept C2777576037 @default.
• W2893787493 hasConcept C2778234585 @default.
• W2893787493 hasConcept C2779222958 @default.
• W2893787493 hasConcept C55493867 @default.
• W2893787493 hasConcept C60644358 @default.
• W2893787493 hasConcept C6350086 @default.
• W2893787493 hasConcept C86803240 @default.
• W2893787493 hasConceptScore W2893787493C100544194 @default.
• W2893787493 hasConceptScore W2893787493C181199279 @default.
• W2893787493 hasConceptScore W2893787493C21565614 @default.
• W2893787493 hasConceptScore W2893787493C2777576037 @default.
• W2893787493 hasConceptScore W2893787493C2778234585 @default.
• W2893787493 hasConceptScore W2893787493C2779222958 @default.
• W2893787493 hasConceptScore W2893787493C55493867 @default.
• W2893787493 hasConceptScore W2893787493C60644358 @default.
• W2893787493 hasConceptScore W2893787493C6350086 @default.
• W2893787493 hasConceptScore W2893787493C86803240 @default.
• W2893787493 hasIssue "8" @default.
• W2893787493 hasLocation W28937874931 @default.
• W2893787493 hasLocation W28937874932 @default.
• W2893787493 hasOpenAccess W2893787493 @default.
• W2893787493 hasPrimaryLocation W28937874931 @default.
• W2893787493 hasRelatedWork W1982799719 @default.
• W2893787493 hasRelatedWork W1994842121 @default.
• W2893787493 hasRelatedWork W2038264310 @default.
• W2893787493 hasRelatedWork W2041935559 @default.
• W2893787493 hasRelatedWork W2148949471 @default.
• W2893787493 hasRelatedWork W2361273201 @default.
• W2893787493 hasRelatedWork W2367019634 @default.
• W2893787493 hasRelatedWork W2888082541 @default.
• W2893787493 hasRelatedWork W3003386732 @default.
• W2893787493 hasRelatedWork W2782794335 @default.
• W2893787493 hasVolume "18" @default.
• W2893787493 isParatext "false" @default.
• W2893787493 isRetracted "false" @default.
• W2893787493 magId "2893787493" @default.

• next