FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893793180> ?p ?o ?g. }

• W2893793180 abstract "Enterovirus (EV) infections are a major threat to global public health, and are responsible for mild respiratory illness, hand, foot and mouth disease (HFMD), acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis epidemic. Among them, HFMD is a common pediatric infectious disease caused by Enteroviruses of the family Picornaviridae including EV-A71, coxsackieviruses (CV)-A2, CV-A6, CV-A10 and CV-A16. Due to lack of vaccines and specific antiviral therapeutics, millions of children still suffer from HFMD. Innate immune system detects foreign invaders by means of a relatively limited number of sensors, such as pattern recognition receptors (PRRs) [eg. Retinoic Acid-Inducible Gene I (RIG-I)-like receptors (RLRs), Toll-like receptors (TLRs) and NOD-like receptors (NLRs)] and even some secreted functional proteins. However, a range of research, highlighted in this review, suggest that Enteroviruses-associated with HFMD have evolved different strategies to avoid detection by innate immunity via different proteases (eg. 2A, 3C, 2C, 3D). Ongoing efforts to better understand virus–host interactions that control innate immunity and then distill how that influences HFMD development, promises to have real-world significance. In this review, we address this complex topic in nine sections including multiple proteins associated with PRR and type I interferon (IFN) signaling. Recognizing how Enteroviruses linked to HFMD evade host innate immune system, we also describe the interactions between them and, finally, suggest future directions to better inform drug development and public health." @default.
• W2893793180 created "2018-10-05" @default.
• W2893793180 creator A5017590136 @default.
• W2893793180 creator A5026585705 @default.
• W2893793180 creator A5063361052 @default.
• W2893793180 date "2018-10-08" @default.
• W2893793180 modified "2023-10-09" @default.
• W2893793180 title "Innate Immunity Evasion by Enteroviruses Linked to Epidemic Hand-Foot-Mouth Disease" @default.
• W2893793180 cites W106469055 @default.
• W2893793180 cites W1482000562 @default.
• W2893793180 cites W1629253818 @default.
• W2893793180 cites W1757088660 @default.
• W2893793180 cites W1833270844 @default.
• W2893793180 cites W1854316463 @default.
• W2893793180 cites W194006493 @default.
• W2893793180 cites W1952166223 @default.
• W2893793180 cites W1973196002 @default.
• W2893793180 cites W1973646620 @default.
• W2893793180 cites W1978042026 @default.
• W2893793180 cites W1984450481 @default.
• W2893793180 cites W1985006736 @default.
• W2893793180 cites W1985204794 @default.
• W2893793180 cites W1988222942 @default.
• W2893793180 cites W1994094364 @default.
• W2893793180 cites W1994709797 @default.
• W2893793180 cites W1995744610 @default.
• W2893793180 cites W2000320283 @default.
• W2893793180 cites W2004829503 @default.
• W2893793180 cites W2017439898 @default.
• W2893793180 cites W2023513354 @default.
• W2893793180 cites W2024062560 @default.
• W2893793180 cites W2027748062 @default.
• W2893793180 cites W2029275361 @default.
• W2893793180 cites W2034664997 @default.
• W2893793180 cites W2036658289 @default.
• W2893793180 cites W2037670698 @default.
• W2893793180 cites W2039634183 @default.
• W2893793180 cites W204088460 @default.
• W2893793180 cites W2048929902 @default.
• W2893793180 cites W2060065563 @default.
• W2893793180 cites W2071115991 @default.
• W2893793180 cites W2071670416 @default.
• W2893793180 cites W2074081620 @default.
• W2893793180 cites W2077424659 @default.
• W2893793180 cites W2078789679 @default.
• W2893793180 cites W2080594285 @default.
• W2893793180 cites W2081434237 @default.
• W2893793180 cites W2085915653 @default.
• W2893793180 cites W2100008113 @default.
• W2893793180 cites W2104430557 @default.
• W2893793180 cites W2107513655 @default.
• W2893793180 cites W2110599330 @default.
• W2893793180 cites W2120596822 @default.
• W2893793180 cites W2128175717 @default.
• W2893793180 cites W2132669016 @default.
• W2893793180 cites W2133449490 @default.
• W2893793180 cites W2141137217 @default.
• W2893793180 cites W2144852254 @default.
• W2893793180 cites W2147255904 @default.
• W2893793180 cites W2150558072 @default.
• W2893793180 cites W2150633180 @default.
• W2893793180 cites W2151713088 @default.
• W2893793180 cites W2153545807 @default.
• W2893793180 cites W2153819224 @default.
• W2893793180 cites W2153880753 @default.
• W2893793180 cites W2158233251 @default.
• W2893793180 cites W2159011095 @default.
• W2893793180 cites W2161824619 @default.
• W2893793180 cites W2162245456 @default.
• W2893793180 cites W2162326083 @default.
• W2893793180 cites W2163279527 @default.
• W2893793180 cites W2163837342 @default.
• W2893793180 cites W2192035028 @default.
• W2893793180 cites W2274018870 @default.
• W2893793180 cites W2305415473 @default.
• W2893793180 cites W2315624236 @default.
• W2893793180 cites W2334359746 @default.
• W2893793180 cites W2401131367 @default.
• W2893793180 cites W2420353244 @default.
• W2893793180 cites W2431987552 @default.
• W2893793180 cites W2518529437 @default.
• W2893793180 cites W2519306994 @default.
• W2893793180 cites W2520408435 @default.
• W2893793180 cites W2523685835 @default.
• W2893793180 cites W2534874190 @default.
• W2893793180 cites W2565468615 @default.
• W2893793180 cites W2567835140 @default.
• W2893793180 cites W2590198016 @default.
• W2893793180 cites W2604278279 @default.
• W2893793180 cites W2607099965 @default.
• W2893793180 cites W2607173880 @default.
• W2893793180 cites W2609669866 @default.
• W2893793180 cites W2612436420 @default.
• W2893793180 cites W2613186245 @default.
• W2893793180 cites W2621549241 @default.
• W2893793180 cites W2733640987 @default.
• W2893793180 cites W2754703278 @default.
• W2893793180 cites W2760108484 @default.
• W2893793180 cites W2767050898 @default.
• W2893793180 cites W2767326000 @default.

• next