Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893796314> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2893796314 abstract "Postoperative neurocognitive disorder (PND) is a major complication in surgical patients, especially the elderly, leading to mild memory impairment after surgery. The underlying pathophysiology remains unknown, although neuroinflammation and blood-brain barrier (BBB) disruption have been increasingly implicated in PND. Emerging evidence suggests that neurokinin-1 receptor (NK-1R), the principal target of proinflammatory neuropeptide substance P (SP), plays a pivotal role in modulating neuroinflammation and BBB integrity. In this study, we used an established mouse model for PND to investigate the effects of a selective NK-1R antagonist L-733,060 on PND-like features after peripheral surgery. Hippocampal SP started to increase at 6 h, peaked at 1 day, and returned to baseline at 3 days after surgery. At 1 day after surgery, NK-1R expression was increased in the hippocampus. At this time point, NK-1R antagonist pretreatment attenuated microgliosis and prevented neutrophil infiltration after surgery. Similarly, proinflammatory cytokines interleukin-1 beta and interleukin-6 were reduced in the hippocampus in NK-1R antagonist-treated mice at 6 h after surgery. Furthermore, surgery-induced BBB disruption, assessed by albumin deposition and expression of tight junction protein claudin-5, was attenuated by NK-1R antagonism at postoperative day 1. Finally, trace fear conditioning test revealed NK-1R antagonism reversed surgery-induced cognitive impairment at 3 days after surgery. Our findings suggest that inhibition of NK-1R signaling protects hippocampus-dependent memory from surgical insult, probably through modulations of neuroinflammation and BBB integrity." @default.
- W2893796314 created "2018-10-05" @default.
- W2893796314 creator A5004592175 @default.
- W2893796314 creator A5005702876 @default.
- W2893796314 creator A5008990095 @default.
- W2893796314 creator A5035201433 @default.
- W2893796314 creator A5048730835 @default.
- W2893796314 date "2018-11-01" @default.
- W2893796314 modified "2023-09-27" @default.
- W2893796314 title "Neurokinin-1 receptor antagonism improves postoperative neurocognitive disorder in mice" @default.
- W2893796314 cites W1575337233 @default.
- W2893796314 cites W1594197304 @default.
- W2893796314 cites W1599368877 @default.
- W2893796314 cites W1601192888 @default.
- W2893796314 cites W1673032473 @default.
- W2893796314 cites W1785816120 @default.
- W2893796314 cites W1973553804 @default.
- W2893796314 cites W2007777786 @default.
- W2893796314 cites W2042175711 @default.
- W2893796314 cites W2047407751 @default.
- W2893796314 cites W2048838719 @default.
- W2893796314 cites W2068201999 @default.
- W2893796314 cites W2073255879 @default.
- W2893796314 cites W2095185818 @default.
- W2893796314 cites W2135735522 @default.
- W2893796314 cites W2145798230 @default.
- W2893796314 cites W2149714164 @default.
- W2893796314 cites W2151402219 @default.
- W2893796314 cites W2172864295 @default.
- W2893796314 cites W2208790547 @default.
- W2893796314 cites W2519583046 @default.
- W2893796314 cites W2531213638 @default.
- W2893796314 cites W2569931142 @default.
- W2893796314 cites W2728433254 @default.
- W2893796314 cites W2762537653 @default.
- W2893796314 cites W2768864227 @default.
- W2893796314 cites W2770121287 @default.
- W2893796314 cites W2770331037 @default.
- W2893796314 cites W2772162736 @default.
- W2893796314 cites W2773263734 @default.
- W2893796314 cites W2788974714 @default.
- W2893796314 cites W2793292264 @default.
- W2893796314 cites W2797955714 @default.
- W2893796314 cites W2806887419 @default.
- W2893796314 doi "https://doi.org/10.1016/j.neulet.2018.09.057" @default.
- W2893796314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30273701" @default.
- W2893796314 hasPublicationYear "2018" @default.
- W2893796314 type Work @default.
- W2893796314 sameAs 2893796314 @default.
- W2893796314 citedByCount "1" @default.
- W2893796314 countsByYear W28937963142019 @default.
- W2893796314 crossrefType "journal-article" @default.
- W2893796314 hasAuthorship W2893796314A5004592175 @default.
- W2893796314 hasAuthorship W2893796314A5005702876 @default.
- W2893796314 hasAuthorship W2893796314A5008990095 @default.
- W2893796314 hasAuthorship W2893796314A5035201433 @default.
- W2893796314 hasAuthorship W2893796314A5048730835 @default.
- W2893796314 hasConcept C126322002 @default.
- W2893796314 hasConcept C134018914 @default.
- W2893796314 hasConcept C164027704 @default.
- W2893796314 hasConcept C170493617 @default.
- W2893796314 hasConcept C2776885963 @default.
- W2893796314 hasConcept C2776914184 @default.
- W2893796314 hasConcept C2778122271 @default.
- W2893796314 hasConcept C2781161787 @default.
- W2893796314 hasConcept C42219234 @default.
- W2893796314 hasConcept C71924100 @default.
- W2893796314 hasConcept C87753298 @default.
- W2893796314 hasConcept C98274493 @default.
- W2893796314 hasConceptScore W2893796314C126322002 @default.
- W2893796314 hasConceptScore W2893796314C134018914 @default.
- W2893796314 hasConceptScore W2893796314C164027704 @default.
- W2893796314 hasConceptScore W2893796314C170493617 @default.
- W2893796314 hasConceptScore W2893796314C2776885963 @default.
- W2893796314 hasConceptScore W2893796314C2776914184 @default.
- W2893796314 hasConceptScore W2893796314C2778122271 @default.
- W2893796314 hasConceptScore W2893796314C2781161787 @default.
- W2893796314 hasConceptScore W2893796314C42219234 @default.
- W2893796314 hasConceptScore W2893796314C71924100 @default.
- W2893796314 hasConceptScore W2893796314C87753298 @default.
- W2893796314 hasConceptScore W2893796314C98274493 @default.
- W2893796314 hasLocation W28937963141 @default.
- W2893796314 hasLocation W28937963142 @default.
- W2893796314 hasOpenAccess W2893796314 @default.
- W2893796314 hasPrimaryLocation W28937963141 @default.
- W2893796314 hasRelatedWork W1974916475 @default.
- W2893796314 hasRelatedWork W1976219263 @default.
- W2893796314 hasRelatedWork W2029100518 @default.
- W2893796314 hasRelatedWork W2051942816 @default.
- W2893796314 hasRelatedWork W2110143838 @default.
- W2893796314 hasRelatedWork W2130742719 @default.
- W2893796314 hasRelatedWork W2375813713 @default.
- W2893796314 hasRelatedWork W2413658046 @default.
- W2893796314 hasRelatedWork W3038304001 @default.
- W2893796314 hasRelatedWork W628893562 @default.
- W2893796314 isParatext "false" @default.
- W2893796314 isRetracted "false" @default.
- W2893796314 magId "2893796314" @default.
- W2893796314 workType "article" @default.