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- W2893804765 abstract "Adult skeletal muscle has a robust capacity for self-repair, owing to synergies between muscle satellite cells and the immune system. In vitro models of muscle self-repair would facilitate the basic understanding of muscle regeneration and the screening of therapies for muscle disease. Here, we show that the incorporation of macrophages into muscle tissues engineered from adult-rat myogenic cells enables near-complete structural and functional repair after cardiotoxic injury in vitro. First, we show that-in contrast with injured neonatal-derived engineered muscle-adult-derived engineered muscle fails to properly self-repair after injury, even when treated with pro-regenerative cytokines. We then show that rat bone-marrow-derived macrophages or human blood-derived macrophages resident within the in vitro engineered tissues stimulate muscle satellite cell-mediated myogenesis while significantly limiting myofibre apoptosis and degeneration. Moreover, bone-marrow-derived macrophages within engineered tissues implanted in a mouse dorsal window-chamber model augmented blood vessel ingrowth, cell survival, muscle regeneration and contractile function." @default.
- W2893804765 created "2018-10-05" @default.
- W2893804765 creator A5008764383 @default.
- W2893804765 creator A5012891700 @default.
- W2893804765 creator A5021822076 @default.
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- W2893804765 creator A5055517288 @default.
- W2893804765 creator A5058397144 @default.
- W2893804765 creator A5066622009 @default.
- W2893804765 creator A5091912766 @default.
- W2893804765 date "2018-10-01" @default.
- W2893804765 modified "2023-10-17" @default.
- W2893804765 title "Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration" @default.
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