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• W2893808660 abstract "Thirty-two new naphthylthiazole derivatives were synthesized with the aim of exploring their antimicrobial effect on multidrug-resistant Gram-positive bacteria. Compounds 25 and 32, with ethylenediamine and methylguanidine side chains, represent the most promising derivatives, as their antibacterial spectrum includes activity against multidrug-resistant staphylococcal and enterococcal strains. Moreover, the new derivatives are highly advantageous over the existing frontline therapeutics for the treatment of multidrug-resistant Gram-positive bacteria. In this vein, compound 25 possesses three attributes: no bacterial resistance was developed against it even after 15 passages, it was very efficient in targeting intracellular pathogens, and it exhibited a concentration-dependent ability to disrupt the preformed bacterial biofilm." @default.
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• W2893808660 date "2018-09-24" @default.
• W2893808660 modified "2023-10-03" @default.
• W2893808660 title "Naphthylthiazoles: Targeting Multidrug-Resistant and Intracellular <i>Staphylococcus aureus</i> with Biofilm Disruption Activity" @default.
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• W2893808660 doi "https://doi.org/10.1021/acsinfecdis.8b00172" @default.
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