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• W2893810995 abstract "Abstract Microglia, the resident immune cells of the central nervous system, play critical roles in neurodevelopment, synaptic pruning, and neuronal wiring. Early in development, microglia migrate via the tangential and radial migration pathways to their final destinations and mature gradually, a process that includes morphological changes. Recent research has implicated microglial abnormality in the etiology of schizophrenia. Since prenatal exposure to viral or bacterial infections due to maternal immune activation (MIA) leads to increased risk of schizophrenia in the offspring during adulthood, the present study systematically investigated how MIA induced by polyinosinic:polycytidylic acid (a mimic of viral double‐stranded RNA) affected microglial immunoreactivity along the migration and maturation trajectories in the brains of male and female rat offspring on postnatal day (PND) 2. The immunohistochemistry revealed significant changes in the density of IBA‐1 immunoreactive cells in the corpus callosum, somatosensory cortex, striatum, and the subregions of the hippocampus of the MIA offspring. The male and female MIA offspring displayed markedly altered microglial immunoreactivity in both the tangential and radial migration, as well as maturation, pathways when compared to their sex‐ and age‐matched controls as evidenced by morphology‐based cell counting. Given the important roles of microglia in synaptic pruning and neuronal wiring and survival, these changes may lead to structural and functional neurodevelopmental abnormalities, and so contribute to the functional deficits observed in juvenile and adult MIA offspring. Future research is required to systematically determine how MIA affects microglial migration and maturation in rat offspring." @default.
• W2893810995 created "2018-10-05" @default.
• W2893810995 creator A5031415650 @default.
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• W2893810995 date "2018-10-12" @default.
• W2893810995 modified "2023-09-26" @default.
• W2893810995 title "Maternal immune activation altered microglial immunoreactivity in the brain of postnatal day 2 rat offspring" @default.
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• W2893810995 doi "https://doi.org/10.1002/syn.22072" @default.
• W2893810995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30256454" @default.
• W2893810995 hasPublicationYear "2018" @default.
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