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- W2893811727 abstract "This chapter reviews evidence for the contribution of genetic factors to bone mineral density (BMD), fracture risk, and response to therapies. Osteoporosis is a condition characterized by low BMD and micro-architectural deterioration leading to increased fracture risk. It is a complex phenotype because its risk is determined by environmental and genetic factors, and possibly their interactions. Although the Fracture Risk Assessment Tool (FRAX) model uses family history of fracture as a risk factor in the risk assessment, no genetic variants have been incorporated into the model. Thus, there is room for genetic research of osteoporosis to improve the prognostic accuracy of these models using genetic variants. Given the ongoing aging of the population worldwide, it is expected that the burden of osteoporosis and osteoporosis-related fractures will become more pronounced in the near future." @default.
- W2893811727 created "2018-10-05" @default.
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- W2893811727 date "2018-09-28" @default.
- W2893811727 modified "2023-09-25" @default.
- W2893811727 title "Translational Genetics of Osteoporosis" @default.
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- W2893811727 doi "https://doi.org/10.1002/9781119266594.ch48" @default.
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