FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893819384> ?p ?o ?g. }

• W2893819384 endingPage "066027" @default.
• W2893819384 startingPage "066027" @default.
• W2893819384 abstract "Objective. Neuroinflammation has long been associated with the performance decline of intracortical microelectrodes (IMEs). Consequently, several strategies, including the use of anti-inflammatories, have been employed to mitigate the inflammation surrounding IMEs. However, these strategies have had limited success towards achieving a chronically viable cortical neural interface, questioning the efficacy of anti-inflammatory approach. Approach. Herein, we conducted a systematic study in rats implanted with functional devices by modulating inflammation via systemic injection of lipopolysaccharide (LPS), dexamethasone (DEX), a combination of both, or none to assess the degree of inflammation on device functionality. We hypothesized that implanted rats treated with LPS will have a negative impact, and rats treated with DEX will have a positive impact on functionality IMEs and histological outcome. Main results. Contrary to our hypothesis, we did not observe adverse effects in recording metrics among different groups with LPS and/or DEX treatment despite alterations in initial pro-inflammatory markers. We also did not observe any functional benefit of anti-inflammatory treatment. Regardless of the treatment conditions, the recording quality degraded at chronic time points. In end-point histology, implanted rats that received LPS had significantly lower NeuN density and higher levels of CD68 surrounding the implant site, indicative of the pro-inflammatory effect of LPS, which, however, contradicted with the recorded results. Significance. Collectively, our results suggest that acute inflammatory events may not be the key driver for functional degradation of IMEs. Future intervention strategies geared towards improving the functional longevity of intracortical devices may benefit using multi-modal approaches rather than a single approach, such as controlling the initial inflammatory response." @default.
• W2893819384 created "2018-10-05" @default.
• W2893819384 creator A5003597745 @default.
• W2893819384 creator A5009865168 @default.
• W2893819384 creator A5013982311 @default.
• W2893819384 creator A5019075609 @default.
• W2893819384 creator A5022232976 @default.
• W2893819384 creator A5082847493 @default.
• W2893819384 date "2018-10-23" @default.
• W2893819384 modified "2023-10-18" @default.
• W2893819384 title "The role of inflammation on the functionality of intracortical microelectrodes" @default.
• W2893819384 cites W1967909505 @default.
• W2893819384 cites W1971567789 @default.
• W2893819384 cites W1972966292 @default.
• W2893819384 cites W1973677172 @default.
• W2893819384 cites W1978902739 @default.
• W2893819384 cites W1982079559 @default.
• W2893819384 cites W1994641975 @default.
• W2893819384 cites W1999169980 @default.
• W2893819384 cites W2001477745 @default.
• W2893819384 cites W2009160991 @default.
• W2893819384 cites W2018371812 @default.
• W2893819384 cites W2021310862 @default.
• W2893819384 cites W2026100867 @default.
• W2893819384 cites W2044124450 @default.
• W2893819384 cites W2045863534 @default.
• W2893819384 cites W2045981383 @default.
• W2893819384 cites W2048767020 @default.
• W2893819384 cites W2052901134 @default.
• W2893819384 cites W2053437895 @default.
• W2893819384 cites W2055750901 @default.
• W2893819384 cites W2064869483 @default.
• W2893819384 cites W2072832306 @default.
• W2893819384 cites W2080865810 @default.
• W2893819384 cites W2084566588 @default.
• W2893819384 cites W2086194837 @default.
• W2893819384 cites W2087704839 @default.
• W2893819384 cites W2090157379 @default.
• W2893819384 cites W2090912350 @default.
• W2893819384 cites W2094664195 @default.
• W2893819384 cites W2095586334 @default.
• W2893819384 cites W2113147953 @default.
• W2893819384 cites W2136167005 @default.
• W2893819384 cites W2144910141 @default.
• W2893819384 cites W2150685615 @default.
• W2893819384 cites W2162988277 @default.
• W2893819384 cites W2167279371 @default.
• W2893819384 cites W2172139367 @default.
• W2893819384 cites W2175869408 @default.
• W2893819384 cites W2595239703 @default.
• W2893819384 cites W2626643673 @default.
• W2893819384 cites W2754909159 @default.
• W2893819384 cites W2792298686 @default.
• W2893819384 cites W2794779835 @default.
• W2893819384 cites W2800636034 @default.
• W2893819384 cites W2801908288 @default.
• W2893819384 doi "https://doi.org/10.1088/1741-2552/aae4b6" @default.
• W2893819384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30260321" @default.
• W2893819384 hasPublicationYear "2018" @default.
• W2893819384 type Work @default.
• W2893819384 sameAs 2893819384 @default.
• W2893819384 citedByCount "22" @default.
• W2893819384 countsByYear W28938193842019 @default.
• W2893819384 countsByYear W28938193842020 @default.
• W2893819384 countsByYear W28938193842021 @default.
• W2893819384 countsByYear W28938193842022 @default.
• W2893819384 countsByYear W28938193842023 @default.
• W2893819384 crossrefType "journal-article" @default.
• W2893819384 hasAuthorship W2893819384A5003597745 @default.
• W2893819384 hasAuthorship W2893819384A5009865168 @default.
• W2893819384 hasAuthorship W2893819384A5013982311 @default.
• W2893819384 hasAuthorship W2893819384A5019075609 @default.
• W2893819384 hasAuthorship W2893819384A5022232976 @default.
• W2893819384 hasAuthorship W2893819384A5082847493 @default.
• W2893819384 hasBestOaLocation W28938193841 @default.
• W2893819384 hasConcept C126322002 @default.
• W2893819384 hasConcept C15744967 @default.
• W2893819384 hasConcept C161790260 @default.
• W2893819384 hasConcept C169760540 @default.
• W2893819384 hasConcept C185592680 @default.
• W2893819384 hasConcept C2776914184 @default.
• W2893819384 hasConcept C2777164566 @default.
• W2893819384 hasConcept C2780311995 @default.
• W2893819384 hasConcept C55493867 @default.
• W2893819384 hasConcept C71924100 @default.
• W2893819384 hasConcept C87753298 @default.
• W2893819384 hasConcept C98274493 @default.
• W2893819384 hasConceptScore W2893819384C126322002 @default.
• W2893819384 hasConceptScore W2893819384C15744967 @default.
• W2893819384 hasConceptScore W2893819384C161790260 @default.
• W2893819384 hasConceptScore W2893819384C169760540 @default.
• W2893819384 hasConceptScore W2893819384C185592680 @default.
• W2893819384 hasConceptScore W2893819384C2776914184 @default.
• W2893819384 hasConceptScore W2893819384C2777164566 @default.
• W2893819384 hasConceptScore W2893819384C2780311995 @default.
• W2893819384 hasConceptScore W2893819384C55493867 @default.
• W2893819384 hasConceptScore W2893819384C71924100 @default.
• W2893819384 hasConceptScore W2893819384C87753298 @default.

• next