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- W2893819854 endingPage "244" @default.
- W2893819854 startingPage "236" @default.
- W2893819854 abstract "Autism spectrum disorder (ASD) affects over 1:100 of the population and costs the UK more than £32bn and the USA more than $175bn (£104bn) annually. Its core symptoms are social and communication difficulties, repetitive behaviours and sensory hyper- or hypo-sensitivities. A highly diverse phenotypic presentation likely reflects its etiological heterogeneity and makes finding treatment targets for ASD challenging. In addition, there are no means to identify biologically responsive individuals who may benefit from specific interventions. There is hope however, and in this review we consolidate how findings from magnetic resonance spectroscopy (MRS) add to the evidence that differences in the brain's excitatory glutamate and inhibitory γ-aminobutyric acid (GABA) balance may be both a key biomarker and a tractable treatment target in ASD." @default.
- W2893819854 created "2018-10-05" @default.
- W2893819854 creator A5033764769 @default.
- W2893819854 creator A5053930432 @default.
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- W2893819854 creator A5089972211 @default.
- W2893819854 creator A5091060167 @default.
- W2893819854 date "2019-03-01" @default.
- W2893819854 modified "2023-10-18" @default.
- W2893819854 title "The contribution of [1H] magnetic resonance spectroscopy to the study of excitation-inhibition in autism" @default.
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