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- W2893823714 endingPage "2067" @default.
- W2893823714 startingPage "2060" @default.
- W2893823714 abstract "Brain injury caused by ischemic insult due to significant reduction or interruption in cerebral blood flow leads to disruption of practically all cellular metabolic pathways. This triggers a complex stress response followed by overstimulation of downstream enzymatic pathways due to massive activation of post-translational modifications (PTM). Mitochondria are one of the most sensitive organelle to ischemic conditions. They become dysfunctional due to extensive fragmentation, inhibition of acetyl‑CoA production, and increased activity of NAD+ consuming enzymes. These pathologic conditions ultimately lead to inhibition of oxidative phosphorylation and mitochondrial ATP production. Both acetyl‑CoA and NAD+ are essential intermediates in cellular bioenergetics metabolism and also serve as substrates for post-translational modifications such as acetylation and ADP‑ribosylation. In this review we discuss ischemia/reperfusion-induced changes in NAD+ and acetyl‑CoA metabolism, how these affect relevant PTMs, and therapeutic approaches that restore the physiological levels of these metabolites leading to promising neuroprotection." @default.
- W2893823714 created "2018-10-05" @default.
- W2893823714 creator A5016274644 @default.
- W2893823714 creator A5050832868 @default.
- W2893823714 creator A5059402016 @default.
- W2893823714 creator A5073944883 @default.
- W2893823714 date "2019-08-01" @default.
- W2893823714 modified "2023-10-18" @default.
- W2893823714 title "Interplay between NAD+ and acetyl‑CoA metabolism in ischemia-induced mitochondrial pathophysiology" @default.
- W2893823714 cites W1517721841 @default.
- W2893823714 cites W1563220284 @default.
- W2893823714 cites W1656115355 @default.
- W2893823714 cites W1874881634 @default.
- W2893823714 cites W1876539387 @default.
- W2893823714 cites W1920479129 @default.
- W2893823714 cites W1963772620 @default.
- W2893823714 cites W1964059126 @default.
- W2893823714 cites W1964539423 @default.
- W2893823714 cites W1965336960 @default.
- W2893823714 cites W1965715919 @default.
- W2893823714 cites W1966329382 @default.
- W2893823714 cites W1970967286 @default.
- W2893823714 cites W1971608015 @default.
- W2893823714 cites W1974237236 @default.
- W2893823714 cites W1974291607 @default.
- W2893823714 cites W1974522384 @default.
- W2893823714 cites W1980355815 @default.
- W2893823714 cites W1983746043 @default.
- W2893823714 cites W1983832155 @default.
- W2893823714 cites W1984616391 @default.
- W2893823714 cites W1989026904 @default.
- W2893823714 cites W1989894088 @default.
- W2893823714 cites W1989937248 @default.
- W2893823714 cites W1992468844 @default.
- W2893823714 cites W1996089864 @default.
- W2893823714 cites W1996813223 @default.
- W2893823714 cites W2001857507 @default.
- W2893823714 cites W2004595433 @default.
- W2893823714 cites W2005037545 @default.
- W2893823714 cites W2005176833 @default.
- W2893823714 cites W2008283809 @default.
- W2893823714 cites W2008622680 @default.
- W2893823714 cites W2010142981 @default.
- W2893823714 cites W2012258115 @default.
- W2893823714 cites W2013511756 @default.
- W2893823714 cites W2015590649 @default.
- W2893823714 cites W2019109313 @default.
- W2893823714 cites W2019240387 @default.
- W2893823714 cites W2020138750 @default.
- W2893823714 cites W2020528945 @default.
- W2893823714 cites W2021786803 @default.
- W2893823714 cites W2022697435 @default.
- W2893823714 cites W2025501814 @default.
- W2893823714 cites W2028178274 @default.
- W2893823714 cites W2033027689 @default.
- W2893823714 cites W2036551825 @default.
- W2893823714 cites W2036599441 @default.
- W2893823714 cites W2037075564 @default.
- W2893823714 cites W2038287622 @default.
- W2893823714 cites W2038498153 @default.
- W2893823714 cites W2040190961 @default.
- W2893823714 cites W2040736163 @default.
- W2893823714 cites W2041255615 @default.
- W2893823714 cites W2043819837 @default.
- W2893823714 cites W2044370075 @default.
- W2893823714 cites W2046050732 @default.
- W2893823714 cites W2051152566 @default.
- W2893823714 cites W2051886358 @default.
- W2893823714 cites W2052943010 @default.
- W2893823714 cites W2053530068 @default.
- W2893823714 cites W2056255780 @default.
- W2893823714 cites W2061984547 @default.
- W2893823714 cites W2064716636 @default.
- W2893823714 cites W2066494673 @default.
- W2893823714 cites W2069882256 @default.
- W2893823714 cites W2072528578 @default.
- W2893823714 cites W2075046972 @default.
- W2893823714 cites W2078484961 @default.
- W2893823714 cites W2083444104 @default.
- W2893823714 cites W2085459880 @default.
- W2893823714 cites W2089822522 @default.
- W2893823714 cites W2090711760 @default.
- W2893823714 cites W2090955970 @default.
- W2893823714 cites W2100322766 @default.
- W2893823714 cites W2101045267 @default.
- W2893823714 cites W2101580126 @default.
- W2893823714 cites W2104954806 @default.
- W2893823714 cites W2105043890 @default.
- W2893823714 cites W2111516110 @default.
- W2893823714 cites W2117473844 @default.
- W2893823714 cites W2118145481 @default.
- W2893823714 cites W2118504152 @default.
- W2893823714 cites W2118649927 @default.
- W2893823714 cites W2124940469 @default.
- W2893823714 cites W2128055033 @default.
- W2893823714 cites W2133727193 @default.
- W2893823714 cites W2136864660 @default.
- W2893823714 cites W2138760860 @default.