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• W2893828732 abstract "Electroacupuncture (EA) has been reported to benefit hypertension, but the underlying mechanisms are still unclear. We hypothesized that EA attenuates hypertension, in part, through modulation of γ -aminobutyric acid (GABA) receptor function in the nucleus tractus solitarii (NTS). In the present study, the long-term effect of EA on GABA receptor function and expression was examined in the NTS of two-kidney, one-clip (2K1C) renovascular hypertensive rats. EA (0.1–0.4 mA, 2 and 15 Hz) was applied at Zusanli (ST36) acupoints overlying the deep fibular nerve for 30 min once a day for two weeks. The results showed that long-term EA treatment improved blood pressure (BP) and markedly restored the baroreflex response in 2K1C hypertensive rats. The increased pressor and depressor responses to microinjection of GABA B receptor agonist and antagonist into the NTS in the hypertensive rats were blunted by the EA treatment. Moreover, EA treatment attenuated the increased GABA B receptor expression in the NTS of hypertensive rats. In contrast, EA had no significant effect on the GABA A receptor function and expression in the NTS of 2K1C hypertensive rats. These findings suggest that the beneficial effects of EA on renovascular hypertension may be through modulation of functional GABA B receptors in the NTS." @default.
• W2893828732 created "2018-10-05" @default.
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• W2893828732 date "2018-09-30" @default.
• W2893828732 modified "2023-10-16" @default.
• W2893828732 title "Electroacupuncture Improves Baroreflex and <i>γ</i>-Aminobutyric Acid Type B Receptor-Mediated Responses in the Nucleus Tractus Solitarii of Hypertensive Rats" @default.
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• W2893828732 doi "https://doi.org/10.1155/2018/8919347" @default.
• W2893828732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6186317" @default.
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• W2893828732 hasPublicationYear "2018" @default.
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