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- W2893835695 abstract "Here we describe our efforts to improve the levels of phosphoglycolipid antibiotic nosokomycin A production by Streptomyces ghanaensis ATCC14672 via genome engineering approaches. Introduction of two extra copies of leucyl tRNA (UUA) gene bldA and one copy of moenomycin biosynthesis gene cluster led, on average, to threefold increase in nosokomycin A titers (up to 1.5 mg/L). Our results validate genome engineering approach as a viable strategy to improve moenomycin production." @default.
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- W2893835695 date "2018-09-25" @default.
- W2893835695 modified "2023-10-16" @default.
- W2893835695 title "Genome Engineering Approaches to Improve Nosokomycin A Production by Streptomyces ghanaensis B38.3" @default.
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- W2893835695 doi "https://doi.org/10.1007/s12088-018-0761-x" @default.
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