Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893838704> ?p ?o ?g. }
- W2893838704 abstract "In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of an aggressive tumour phenotype. This transition endows tumour cells with the capacity to escape from the confines of the primary tumour and metastasise to secondary sites. In this review, we will discuss how N-cadherin actively promotes the metastatic behaviour of tumour cells, including its involvement in critical signalling pathways which mediate these events. In addition, we will explore the emerging role of N-cadherin in haematological malignancies, including bone marrow homing and microenvironmental protection to anti-cancer agents. Finally, we will discuss the evidence that N-cadherin may be a viable therapeutic target to inhibit cancer metastasis and increase tumour cell sensitivity to existing anti-cancer therapies." @default.
- W2893838704 created "2018-10-05" @default.
- W2893838704 creator A5007582883 @default.
- W2893838704 creator A5011048271 @default.
- W2893838704 creator A5016926995 @default.
- W2893838704 creator A5038809285 @default.
- W2893838704 creator A5073344894 @default.
- W2893838704 date "2018-10-01" @default.
- W2893838704 modified "2023-10-14" @default.
- W2893838704 title "N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer" @default.
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