FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893840462> ?p ?o ?g. }

• W2893840462 abstract "Background Lymphatic vessels interconnect with blood vessels to form an elaborate system that aids in the control of tissue pressure and edema formation. Although the lymphatic system has been known to exist in a heart, little is known about the role the cardiac lymphatic system plays in the development of heart failure. Methods and Results Mice (C57 BL /6J, male, 8 to 12 weeks of age) were subjected to either myocardial ischemia or myocardial ischemia and reperfusion for up to 28 days. Analysis revealed that both models increased the protein expression of vascular endothelial growth factor C and VEGF receptor 3 starting at 1 day after the onset of injury, whereas a significant increase in lymphatic vessel density was observed starting at 3 days. Further studies aimed to determine the consequences of inhibiting the endogenous lymphangiogenesis response on the development of heart failure. Using 2 different pharmacological approaches, we found that inhibiting VEGF receptor 3 with MAZ ‐51 and blocking endogenous vascular endothelial growth factor C with a neutralizing antibody blunted the increase in lymphatic vessel density, blunted lymphatic transport, increased inflammation, increased edema, and increased cardiac dysfunction. Subsequent studies revealed that augmentation of the endogenous lymphangiogenesis response with vascular endothelial growth factor C treatment reduced inflammation, reduced edema, and improved cardiac dysfunction. Conclusions These results suggest that the endogenous lymphangiogenesis response plays an adaptive role in the development of ischemic‐induced heart failure and supports the emerging concept that therapeutic lymphangiogenesis is a promising new approach for the treatment of cardiovascular disease." @default.
• W2893840462 created "2018-10-05" @default.
• W2893840462 creator A5001713604 @default.
• W2893840462 creator A5005521265 @default.
• W2893840462 creator A5016527938 @default.
• W2893840462 creator A5022886115 @default.
• W2893840462 creator A5034179596 @default.
• W2893840462 creator A5035386999 @default.
• W2893840462 creator A5044374576 @default.
• W2893840462 creator A5053143630 @default.
• W2893840462 creator A5059574997 @default.
• W2893840462 creator A5070133394 @default.
• W2893840462 creator A5072494696 @default.
• W2893840462 creator A5077535251 @default.
• W2893840462 date "2018-10-02" @default.
• W2893840462 modified "2023-10-16" @default.
• W2893840462 title "Impact of Lymphangiogenesis on Cardiac Remodeling After Ischemia and Reperfusion Injury" @default.
• W2893840462 cites W1568237782 @default.
• W2893840462 cites W1812805390 @default.
• W2893840462 cites W1972516670 @default.
• W2893840462 cites W1974366525 @default.
• W2893840462 cites W1982486040 @default.
• W2893840462 cites W1984996259 @default.
• W2893840462 cites W1985232927 @default.
• W2893840462 cites W1985862855 @default.
• W2893840462 cites W1989002632 @default.
• W2893840462 cites W1991298929 @default.
• W2893840462 cites W1992101966 @default.
• W2893840462 cites W1992532574 @default.
• W2893840462 cites W2003450086 @default.
• W2893840462 cites W2005381807 @default.
• W2893840462 cites W2022123660 @default.
• W2893840462 cites W2022366199 @default.
• W2893840462 cites W2030253572 @default.
• W2893840462 cites W2039501347 @default.
• W2893840462 cites W2040089666 @default.
• W2893840462 cites W2043302297 @default.
• W2893840462 cites W2043815098 @default.
• W2893840462 cites W2048506716 @default.
• W2893840462 cites W2054193907 @default.
• W2893840462 cites W2054512362 @default.
• W2893840462 cites W2054726115 @default.
• W2893840462 cites W2057697484 @default.
• W2893840462 cites W2064752763 @default.
• W2893840462 cites W2071745805 @default.
• W2893840462 cites W2073126451 @default.
• W2893840462 cites W2084850221 @default.
• W2893840462 cites W2087636391 @default.
• W2893840462 cites W2089892676 @default.
• W2893840462 cites W2094705328 @default.
• W2893840462 cites W2095002343 @default.
• W2893840462 cites W2097384952 @default.
• W2893840462 cites W2097731330 @default.
• W2893840462 cites W2099703857 @default.
• W2893840462 cites W2106448072 @default.
• W2893840462 cites W2107312159 @default.
• W2893840462 cites W2132992599 @default.
• W2893840462 cites W2137100240 @default.
• W2893840462 cites W2137571589 @default.
• W2893840462 cites W2149163652 @default.
• W2893840462 cites W2149177522 @default.
• W2893840462 cites W2171311487 @default.
• W2893840462 cites W2315219108 @default.
• W2893840462 cites W2336433526 @default.
• W2893840462 cites W2344803633 @default.
• W2893840462 doi "https://doi.org/10.1161/jaha.118.009565" @default.
• W2893840462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6404883" @default.
• W2893840462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30371303" @default.
• W2893840462 hasPublicationYear "2018" @default.
• W2893840462 type Work @default.
• W2893840462 sameAs 2893840462 @default.
• W2893840462 citedByCount "40" @default.
• W2893840462 countsByYear W28938404622019 @default.
• W2893840462 countsByYear W28938404622020 @default.
• W2893840462 countsByYear W28938404622021 @default.
• W2893840462 countsByYear W28938404622022 @default.
• W2893840462 countsByYear W28938404622023 @default.
• W2893840462 crossrefType "journal-article" @default.
• W2893840462 hasAuthorship W2893840462A5001713604 @default.
• W2893840462 hasAuthorship W2893840462A5005521265 @default.
• W2893840462 hasAuthorship W2893840462A5016527938 @default.
• W2893840462 hasAuthorship W2893840462A5022886115 @default.
• W2893840462 hasAuthorship W2893840462A5034179596 @default.
• W2893840462 hasAuthorship W2893840462A5035386999 @default.
• W2893840462 hasAuthorship W2893840462A5044374576 @default.
• W2893840462 hasAuthorship W2893840462A5053143630 @default.
• W2893840462 hasAuthorship W2893840462A5059574997 @default.
• W2893840462 hasAuthorship W2893840462A5070133394 @default.
• W2893840462 hasAuthorship W2893840462A5072494696 @default.
• W2893840462 hasAuthorship W2893840462A5077535251 @default.
• W2893840462 hasBestOaLocation W28938404621 @default.
• W2893840462 hasConcept C103041312 @default.
• W2893840462 hasConcept C121608353 @default.
• W2893840462 hasConcept C126322002 @default.
• W2893840462 hasConcept C142724271 @default.
• W2893840462 hasConcept C146285616 @default.
• W2893840462 hasConcept C164705383 @default.
• W2893840462 hasConcept C167734588 @default.
• W2893840462 hasConcept C181152851 @default.
• W2893840462 hasConcept C2776636583 @default.

• next