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• W2893842402 abstract "Genome-wide association and candidate gene studies have identified COL4A1 and COL4A2 as risk genes for intracerebral hemorrhage (ICH), suggesting that the disrupted collagen architecture could be a contributory factor in disease onset. Environmental factors that disrupt the vascular collagen architecture may therefore bring about gene–environmental interactions. Certain oral strains of Streptococcus mutans expressing Cnm, a collagen-binding protein, have been found to be responsible for ICH in a preclinical study. In support of this finding, a population-based study showed a close association between Cnm-positive Streptococcus mutans with cerebral microbleeds, a precursor of ICH, and a hospital-based study between such bacteria with cerebral microbleeds and ICH. Taken together, these findings suggest that Cnm-positive Streptococcus mutans serve as an important environmental factor in ICH." @default.
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• W2893842402 date "2018-11-01" @default.
• W2893842402 modified "2023-10-14" @default.
• W2893842402 title "Collagen-binding <i>Streptococcus mutans</i> tied to cerebral microbleeds and intracerebral hemorrhage" @default.
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• W2893842402 doi "https://doi.org/10.2217/fnl-2018-0016" @default.
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