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- W2893843196 abstract "Background High levels of antiphospholipid antibodies (aPL) are associated predominantly with a higher risk of thrombosis, however, information about differential levels according underlying diagnosis is less well known. Objectives Our aim was to compared serum levels of 2 novel aPL (anti-phosphatidylserine/prothrombin (PS/PT) antibodies and anti domain 1 against s2 glycoprotein I (anti-D1 B2GP1)) and “classic” (anticardiolipin, aCL and anti B2GP1 antibodies) among patients with primary APS, SLE with and without thrombosis Methods In this cross-sectional study, Anti-D1 B2GPI antibodies were tested using a chemiluminescent immunoassay (QUANTA Flash, Inova Diagnostics). In addition, anti PS/PT (IgG and IgM), aCL (IgG and IgM) and anti B2GP1 (IgG and IgM) were measured at the same time by ELISA techniques (QUANTA Lite, Inova Diagnostics). Lupus anticoagulant was detected according to the guidelines of the International Society on Thrombosis and Haemostasia. Differences in mean values between groups were analysed with the Mann-Whitney U test for comparison of 2 groups Results One hundred and seventy three patients were included, 87% of patients were female with a mean age of 33±12 years. 150 patients had SLE and 23 patients primary APS. Fifty five (31%) out of 177 had history of thrombosis and 41 (23%) of pregnancy losses. Levels of IgM aCL, IgM B2GP1, IgM Anti PS/PT and total antibodies against Anti-D1 B2GP1 were significantly higher in patients with primary APS than in patients with SLE and thrombosis (see figure 1).IgG anti PS/PT (75.9±91.3 vs 27.4±39.3 IU, p 0.07) were more common in patients with primary APS than SLE with thrombosis. No significant differences were found in terms of thrombotic events among both groups Conclusions Patients with primary APS have significant higher serum levels of anti PS/PT and anti-D1 B2GP1 antibodies and “classic” aPL (aCl and anti B2GP1) antibodies than patients with SLE with thrombosis. Whether if these titers are useful to differentiate patients with primary and secondary APS requires further analysis in prospective studies. Acknowledgements Anti D1- B2GPI antibodies antibodies were provided by Inova, Werfen, Colombia Disclosure of Interest J. A. Gomez-Puerta Speakers bureau: Werfen/Inova, T. Urrego: None declared, A. Hernandez: None declared, S. Ruiz: None declared, S. M. Osorno: None declared, C. Rua: None declared, J. Duque Botero: None declared, A. Vanegas-Garcia: None declared, C. H. Munoz: None declared, L. A. Gonzalez: None declared, G. Vasquez: None declared" @default.
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- W2893843196 date "2018-06-01" @default.
- W2893843196 modified "2023-10-18" @default.
- W2893843196 title "SAT0439 Differential levels of novel and classic antiphospholipid antibodies among patients with primary antiphospholipid syndrome and systemic lupus erythematosus" @default.
- W2893843196 doi "https://doi.org/10.1136/annrheumdis-2018-eular.4588" @default.
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