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- W2893843599 abstract "Summary When recombinant DNA technology was developed more than 40 years ago, no one could have imagined the impact it would have on both society and the scientific community. In the field of genetic engineering, the most important tool developed was the plasmid vector. This technology has been continuously expanding and undergoing adaptations. Here, we provide a detailed view following the evolution of vectors built throughout the years destined to study microorganisms and their peculiarities, including those whose genomes can only be revealed through metagenomics. We remark how synthetic biology became a turning point in designing these genetic tools to create meaningful innovations. We have placed special focus on the tools for engineering bacteria and fungi (both yeast and filamentous fungi) and those available to construct metagenomic libraries. Based on this overview, future goals would include the development of modular vectors bearing standardized parts and orthogonally designed circuits, a task not fully addressed thus far. Finally, we present some challenges that should be overcome to enable the next generation of vector design and ways to address it." @default.
- W2893843599 created "2018-10-05" @default.
- W2893843599 creator A5022816863 @default.
- W2893843599 creator A5042634573 @default.
- W2893843599 creator A5051413186 @default.
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- W2893843599 creator A5076331941 @default.
- W2893843599 creator A5078545139 @default.
- W2893843599 creator A5079570801 @default.
- W2893843599 date "2018-09-26" @default.
- W2893843599 modified "2023-10-15" @default.
- W2893843599 title "The art of vector engineering: towards the construction of next-generation genetic tools" @default.
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