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- W2893844225 abstract "Non-muscle-invasive bladder cancer (NMIBC), the most prevalent type of bladder cancer, accounts for ~75% of bladder cancer diagnoses. This disease has a 50% risk of recurrence and 20% risk of progression within 5 years, despite the use of intravesical adjuvant treatments (such as BCG or mitomycin C) that are recommended by clinical guidelines. Intravesical device-assisted therapies, such as radiofrequency-induced thermochemotherapeutic effect (RITE), conductive hyperthermic chemotherapy, and electromotive drug administration (EMDA), have shown promising efficacy. These device-assisted treatments are an attractive alternative to BCG, as issues with supply have been a problem in some countries. RITE might be an effective treatment option for some patients who have experienced BCG failure and are not candidates for radical cystectomy. Data from trials using EMDA suggest that it is effective in high-risk disease but requires further validation, and results of randomized trials are eagerly awaited for conductive hyperthermic chemotherapy. Considerable heterogeneity in patient cohorts, treatment sessions, use of maintenance regimens, and single-arm study design makes it difficult to draw solid conclusions, although randomized controlled trials have been reported for RITE and EMDA." @default.
- W2893844225 created "2018-10-05" @default.
- W2893844225 creator A5079640210 @default.
- W2893844225 creator A5080584855 @default.
- W2893844225 date "2018-09-25" @default.
- W2893844225 modified "2023-09-30" @default.
- W2893844225 title "Intravesical device-assisted therapies for non-muscle-invasive bladder cancer" @default.
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- W2893844225 doi "https://doi.org/10.1038/s41585-018-0092-z" @default.
- W2893844225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254383" @default.
- W2893844225 hasPublicationYear "2018" @default.
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