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- W2893846083 endingPage "2243" @default.
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- W2893846083 abstract "Non-intentionally added substances (NIAS) are chemical impurities which can migrate from packaging materials (FCM) into food. Safety assessment of NIAS is required by European law, but currently there is no comprehensive testing strategy available. In this context, one key element is to get insight on the potential presence of genotoxic NIAS in FCM migrates. This raises questions about the limit at which genotoxins can be detected in complex mixtures such as FCM migrates, and if such limits of detection (LOD) would be compatible with safety. In this context, the present review assesses the suitability of the Ames assay to address genotoxicity of FCM migrates. Lowest effective concentrations of packaging-related and other chemicals in test media were retrieved from scientific literature and used as surrogates of LODs to be benchmarked against a value of 0.01 mg kg-1 (10 ppb) in migrates. This is a pragmatic threshold used in FCM safety evaluation to prioritise substances requiring proper identification and risk assessment. The analysis of the data shows that only potent genotoxins can theoretically be detectable at a level of 0.01 mg kg-1 in migrates or food. Only a minority (10%) of genotoxic chemicals reported to be associated with FCMs could be picked up at a level of 0.01 mg kg-1 or lower. Overall, this review shows that the Ames test in its present form cannot be used as standalone method for evaluating the genotoxic potential of FCM migrates, but must be used together with other information from analytical chemistry and FCM manufacturing." @default.
- W2893846083 created "2018-10-05" @default.
- W2893846083 creator A5010548237 @default.
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- W2893846083 date "2018-09-26" @default.
- W2893846083 modified "2023-10-13" @default.
- W2893846083 title "Suitability of the Ames test to characterise genotoxicity of food contact material migrates" @default.
- W2893846083 cites W1587460426 @default.
- W2893846083 cites W1964938134 @default.
- W2893846083 cites W1967016556 @default.
- W2893846083 cites W1967172867 @default.
- W2893846083 cites W1969097249 @default.
- W2893846083 cites W1971402000 @default.
- W2893846083 cites W1971561345 @default.
- W2893846083 cites W1973879072 @default.
- W2893846083 cites W1979162175 @default.
- W2893846083 cites W1990994423 @default.
- W2893846083 cites W1991138963 @default.
- W2893846083 cites W1992690491 @default.
- W2893846083 cites W1993991916 @default.
- W2893846083 cites W1999432535 @default.
- W2893846083 cites W2001044404 @default.
- W2893846083 cites W2002292710 @default.
- W2893846083 cites W2004678494 @default.
- W2893846083 cites W2004944975 @default.
- W2893846083 cites W2005156172 @default.
- W2893846083 cites W2006939864 @default.
- W2893846083 cites W2013571301 @default.
- W2893846083 cites W2013831237 @default.
- W2893846083 cites W2014040880 @default.
- W2893846083 cites W2020032592 @default.
- W2893846083 cites W2021001730 @default.
- W2893846083 cites W2024195829 @default.
- W2893846083 cites W2025919994 @default.
- W2893846083 cites W2026385820 @default.
- W2893846083 cites W2027407337 @default.
- W2893846083 cites W2029985758 @default.
- W2893846083 cites W2032090234 @default.
- W2893846083 cites W2032155952 @default.
- W2893846083 cites W2033885649 @default.
- W2893846083 cites W2034807229 @default.
- W2893846083 cites W2034969136 @default.
- W2893846083 cites W2037037988 @default.
- W2893846083 cites W2037735263 @default.
- W2893846083 cites W2043274592 @default.
- W2893846083 cites W2045873169 @default.
- W2893846083 cites W2047516953 @default.
- W2893846083 cites W2048853937 @default.
- W2893846083 cites W2048978778 @default.
- W2893846083 cites W2049692967 @default.
- W2893846083 cites W2050601207 @default.
- W2893846083 cites W2051103063 @default.
- W2893846083 cites W2053384460 @default.
- W2893846083 cites W2060222479 @default.
- W2893846083 cites W2064195202 @default.
- W2893846083 cites W2067396742 @default.
- W2893846083 cites W2070420894 @default.
- W2893846083 cites W2074397140 @default.
- W2893846083 cites W2076140241 @default.
- W2893846083 cites W2078007780 @default.
- W2893846083 cites W2083153190 @default.
- W2893846083 cites W2083352982 @default.
- W2893846083 cites W2090617339 @default.
- W2893846083 cites W2091311031 @default.
- W2893846083 cites W2093167885 @default.
- W2893846083 cites W2093871410 @default.
- W2893846083 cites W2122228020 @default.
- W2893846083 cites W2134433202 @default.
- W2893846083 cites W2147403657 @default.
- W2893846083 cites W2150456365 @default.
- W2893846083 cites W2159082057 @default.
- W2893846083 cites W2164842022 @default.
- W2893846083 cites W2166753136 @default.
- W2893846083 cites W2166975193 @default.
- W2893846083 cites W2186188114 @default.
- W2893846083 cites W2279619627 @default.
- W2893846083 cites W2332727735 @default.
- W2893846083 cites W2343449871 @default.
- W2893846083 cites W2361300289 @default.
- W2893846083 cites W2462079599 @default.
- W2893846083 cites W2474344105 @default.
- W2893846083 cites W2552693506 @default.
- W2893846083 cites W2556371575 @default.
- W2893846083 cites W2611407337 @default.
- W2893846083 cites W2619672561 @default.
- W2893846083 cites W2620629414 @default.
- W2893846083 cites W2738272971 @default.
- W2893846083 cites W2744527592 @default.
- W2893846083 cites W4235201712 @default.
- W2893846083 cites W4251980620 @default.
- W2893846083 doi "https://doi.org/10.1080/19440049.2018.1519259" @default.
- W2893846083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257137" @default.