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- W2893849874 abstract "The preparation, characterization and evaluation of γ-cyclodextrin/steviolbioside (γ-CD/Sbio) inclusion complex was evaluated. Sbio is a typical steviol glycoside, which is used as a sucrose substitute and has health benefits. To overcome Sbio's poor aqueous solubility and low bioavailability, γ-CD/Sbio was prepared using a co-evaporation method. The possible bonding mode of Sbio with α-CD, β-CD and γ-CD was identified using AutoDock software. Host molecular screening tests showed that γ-CD was the optimal host molecule. The solubility of Sbio increased 31 fold, with a 1:1 γ-CD/Sbio inclusion complex. HPLC, FT-IR, TGA, XRD, SEM and NMR were used to characterize the γ-CD/Sbio. Based on an in vitro test, γ-CD/Sbio was more stable than Sbio with cecal contents. In addition, in vivo pharmacokinetics were done. The Cmax and AUC of γ-CD/Sbio were 2.4 times higher than for Sbio. Overall, the solubility and oral bioavailability of Sbio was significantly improved after inclusion." @default.
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- W2893849874 date "2018-12-01" @default.
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- W2893849874 title "Preparation, characterization and evaluation of an inclusion complex of steviolbioside with γ-cyclodextrin" @default.
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- W2893849874 doi "https://doi.org/10.1016/j.fbio.2018.09.007" @default.
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