Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893852267> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2893852267 abstract "Background: Recent developments in fast dissolving tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets.The main objective of the present study is to formulate fast dissolving tablet of Lornoxicam by direct compression method.Methods: Guar gum and crospovidone were used as natural and synthetic superdisintegrants respectively. Fast dissolving tablet of Lornoxicam were prepared by direct compression technique using three different approaches; superdisintegrant addition, sublimation, and solid dispersion.Results: IR and DSC studies showed no interaction between the drug and the excipients. All formulation showed disintegration time ranging from 16.09-42.54 second. Wetting time and disintegration time decreased by increasing the super disintegrant concentration from 2.5% to 5% w/w. Formulae L16 gave the best in- vitro disintegration and dissolution results, which would be due to swelling effect of Gaur gum and amorphization of the drug during the solid dispersion preparation.The best formulation L16 was subjected to stability testing for 3 month and results showed no significant change in appearance, hardness, drug content and dissolution profile of the tablets, hence tablet is stable throughout its stability studies.Conclusion: It was concluded that fast dissolving tablets of Lornoxicam were formulated successfully with desired characteristics which disintegrated rapidly; provided rapid onset of action; and enhanced the patient convenience and compliance.JMMIHS,2018;4(1):86-102" @default.
- W2893852267 created "2018-10-05" @default.
- W2893852267 creator A5015773450 @default.
- W2893852267 creator A5044299667 @default.
- W2893852267 creator A5046584923 @default.
- W2893852267 creator A5060328570 @default.
- W2893852267 date "2018-09-22" @default.
- W2893852267 modified "2023-09-25" @default.
- W2893852267 title "Various approaches to enhance the dissolution of Lornoxicam fast dissolving tablets prepared by using different categories of superdisintegrants: A comparative study" @default.
- W2893852267 doi "https://doi.org/10.3126/jmmihs.v4i1.21147" @default.
- W2893852267 hasPublicationYear "2018" @default.
- W2893852267 type Work @default.
- W2893852267 sameAs 2893852267 @default.
- W2893852267 citedByCount "1" @default.
- W2893852267 countsByYear W28938522672019 @default.
- W2893852267 crossrefType "journal-article" @default.
- W2893852267 hasAuthorship W2893852267A5015773450 @default.
- W2893852267 hasAuthorship W2893852267A5044299667 @default.
- W2893852267 hasAuthorship W2893852267A5046584923 @default.
- W2893852267 hasAuthorship W2893852267A5060328570 @default.
- W2893852267 hasBestOaLocation W28938522671 @default.
- W2893852267 hasConcept C159985019 @default.
- W2893852267 hasConcept C178790620 @default.
- W2893852267 hasConcept C185592680 @default.
- W2893852267 hasConcept C191168616 @default.
- W2893852267 hasConcept C192562407 @default.
- W2893852267 hasConcept C2776035855 @default.
- W2893852267 hasConcept C2779040406 @default.
- W2893852267 hasConcept C2780820201 @default.
- W2893852267 hasConcept C43617362 @default.
- W2893852267 hasConcept C521977710 @default.
- W2893852267 hasConcept C71924100 @default.
- W2893852267 hasConcept C88380143 @default.
- W2893852267 hasConcept C98274493 @default.
- W2893852267 hasConceptScore W2893852267C159985019 @default.
- W2893852267 hasConceptScore W2893852267C178790620 @default.
- W2893852267 hasConceptScore W2893852267C185592680 @default.
- W2893852267 hasConceptScore W2893852267C191168616 @default.
- W2893852267 hasConceptScore W2893852267C192562407 @default.
- W2893852267 hasConceptScore W2893852267C2776035855 @default.
- W2893852267 hasConceptScore W2893852267C2779040406 @default.
- W2893852267 hasConceptScore W2893852267C2780820201 @default.
- W2893852267 hasConceptScore W2893852267C43617362 @default.
- W2893852267 hasConceptScore W2893852267C521977710 @default.
- W2893852267 hasConceptScore W2893852267C71924100 @default.
- W2893852267 hasConceptScore W2893852267C88380143 @default.
- W2893852267 hasConceptScore W2893852267C98274493 @default.
- W2893852267 hasLocation W28938522671 @default.
- W2893852267 hasOpenAccess W2893852267 @default.
- W2893852267 hasPrimaryLocation W28938522671 @default.
- W2893852267 hasRelatedWork W1573521801 @default.
- W2893852267 hasRelatedWork W2054583946 @default.
- W2893852267 hasRelatedWork W2135297703 @default.
- W2893852267 hasRelatedWork W2184271686 @default.
- W2893852267 hasRelatedWork W2358282523 @default.
- W2893852267 hasRelatedWork W2730591882 @default.
- W2893852267 hasRelatedWork W2893852267 @default.
- W2893852267 hasRelatedWork W3208724517 @default.
- W2893852267 hasRelatedWork W2185838764 @default.
- W2893852267 hasRelatedWork W2189554673 @default.
- W2893852267 isParatext "false" @default.
- W2893852267 isRetracted "false" @default.
- W2893852267 magId "2893852267" @default.
- W2893852267 workType "article" @default.