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- W2893852470 abstract "Decellularized matrices of biologic tissue have performed well as wound care dressings. Extracellular matrix-based dressings are subject to rapid degradation by excessive protease activity at the wound environment. Stabilized, acellular, equine pericardial collagen matrix (sPCM) wound care dressing is flexible cross-linked proteolytic enzyme degradation resistant. sPCM was structurally characterized utilizing scanning electron and atomic force microscopy. In murine excisional wounds, sPCM was effective in mounting an acute inflammatory response. Postwound inflammation resolved rapidly, as indicated by elevated levels of IL-10, arginase-1, and VEGF, and lowering of IL-1β and TNF-α. sPCM induced antimicrobial proteins S100A9 and β-defensin-1 in keratinocytes. Adherence of Pseudomonas aeruginosa and Staphylococcus aureus on sPCM pre-exposed to host immune cells in vivo was inhibited. Excisional wounds dressed with sPCM showed complete closure at d 14, while control wounds remained open. sPCM accelerated wound re-epithelialization. sPCM not only accelerated wound closure but also improved the quality of healing by increased collagen deposition and maturation. Thus, sPCM is capable of presenting scaffold functionality during the course of wound healing. In addition to inducing endogenous antimicrobial defense systems, the dressing itself has properties that minimize biofilm formation. It mounts robust inflammation, a process that rapidly resolves, making way for wound healing to advance.-El Masry, M. S., Chaffee, S., Das Ghatak, P., Mathew-Steiner, S. S., Das, A., Higuita-Castro, N., Roy, S., Anani, R. A., Sen, C. K. Stabilized collagen matrix dressing improves wound macrophage function and epithelialization." @default.
- W2893852470 created "2018-10-05" @default.
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- W2893852470 date "2018-09-27" @default.
- W2893852470 modified "2023-10-15" @default.
- W2893852470 title "Stabilized collagen matrix dressing improves wound macrophage function and epithelialization" @default.
- W2893852470 cites W1496902349 @default.
- W2893852470 cites W1526243437 @default.
- W2893852470 cites W1529263306 @default.
- W2893852470 cites W1540375023 @default.
- W2893852470 cites W1566992315 @default.
- W2893852470 cites W1572306833 @default.
- W2893852470 cites W1635522980 @default.
- W2893852470 cites W1845549666 @default.
- W2893852470 cites W1918466998 @default.
- W2893852470 cites W1959506586 @default.
- W2893852470 cites W1964758221 @default.
- W2893852470 cites W1965006954 @default.
- W2893852470 cites W1966158599 @default.
- W2893852470 cites W1974476177 @default.
- W2893852470 cites W1983772892 @default.
- W2893852470 cites W1984358129 @default.
- W2893852470 cites W1987879189 @default.
- W2893852470 cites W1989021197 @default.
- W2893852470 cites W1989998611 @default.
- W2893852470 cites W1990677784 @default.
- W2893852470 cites W1992774222 @default.
- W2893852470 cites W2001220125 @default.
- W2893852470 cites W2002280012 @default.
- W2893852470 cites W2004268699 @default.
- W2893852470 cites W2007088223 @default.
- W2893852470 cites W2008154182 @default.
- W2893852470 cites W2008565536 @default.
- W2893852470 cites W2008862006 @default.
- W2893852470 cites W2012417909 @default.
- W2893852470 cites W2016193552 @default.
- W2893852470 cites W2016714257 @default.
- W2893852470 cites W2020799333 @default.
- W2893852470 cites W2024604966 @default.
- W2893852470 cites W2026578487 @default.
- W2893852470 cites W2027991714 @default.
- W2893852470 cites W2029738070 @default.
- W2893852470 cites W2031828932 @default.
- W2893852470 cites W2035733625 @default.
- W2893852470 cites W2042570690 @default.
- W2893852470 cites W2043960873 @default.
- W2893852470 cites W204511859 @default.
- W2893852470 cites W2050145258 @default.
- W2893852470 cites W2050382572 @default.
- W2893852470 cites W2054472394 @default.
- W2893852470 cites W2055336483 @default.
- W2893852470 cites W2056914993 @default.
- W2893852470 cites W2057198053 @default.
- W2893852470 cites W2066902095 @default.
- W2893852470 cites W2070995184 @default.
- W2893852470 cites W2071107715 @default.
- W2893852470 cites W2071724348 @default.
- W2893852470 cites W2075761329 @default.
- W2893852470 cites W2080184728 @default.
- W2893852470 cites W2081407130 @default.
- W2893852470 cites W2081537251 @default.
- W2893852470 cites W2082516633 @default.
- W2893852470 cites W2089559505 @default.
- W2893852470 cites W2091128689 @default.
- W2893852470 cites W2091371907 @default.
- W2893852470 cites W2092386544 @default.
- W2893852470 cites W2099599731 @default.
- W2893852470 cites W2099707643 @default.
- W2893852470 cites W2104159258 @default.
- W2893852470 cites W2104233820 @default.
- W2893852470 cites W2118954259 @default.
- W2893852470 cites W2120472250 @default.
- W2893852470 cites W2127845947 @default.
- W2893852470 cites W2133382379 @default.
- W2893852470 cites W2133496985 @default.
- W2893852470 cites W2135284391 @default.
- W2893852470 cites W2141489905 @default.
- W2893852470 cites W2147038478 @default.
- W2893852470 cites W2151364826 @default.
- W2893852470 cites W2152773911 @default.
- W2893852470 cites W2153461044 @default.
- W2893852470 cites W2157705461 @default.
- W2893852470 cites W2159560463 @default.
- W2893852470 cites W2161767194 @default.
- W2893852470 cites W2163386417 @default.
- W2893852470 cites W2169938366 @default.
- W2893852470 cites W2176823143 @default.
- W2893852470 cites W2281341266 @default.
- W2893852470 cites W2325727928 @default.
- W2893852470 cites W2403287989 @default.