Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893853908> ?p ?o ?g. }
- W2893853908 abstract "Because of the profound financial crisis that commenced in Greece in 2010, severe cuts in health care spending and other restriction measures led to significant delays in the reimbursement of novel antineoplastic agents. In 2011, the Hellenic Society of Medical Oncology initiated a program of early access to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for the treatment of patients with advanced, EGFR-mutant non-small-cell lung cancer (NSCLC). We evaluated treatment patterns and clinical outcomes in patients with EGFR-mutant or wild-type disease treated at a large center in Greece throughout the period of financial crisis.From 2011 through 2015, 252 patients with newly diagnosed advanced NSCLC were treated at the Department of Medical Oncology of the Papageorgiou Hospital, a tertiary cancer center in northern Greece. We retrospectively reviewed patient medical records to obtain clinicopathologic characteristics, EGFR mutation status, and follow-up data. The primary end point was time to treatment failure.Of the 198 evaluable patients, 25 (12%) had EGFR mutations. All patients with EGFR mutations except one received treatment with an EGFR tyrosine kinase inhibitor. Median times to treatment failure for patients with EGFR-mutant and wild-type disease were 15.8 and 7.1 months, respectively (hazard ratio, 0.58; 95% CI, 0.35 to 0.95; P = .031). There was no difference in overall survival between the two groups ( P = .293). No deviation from treatment guidelines or discontinuation of treatment regimens occurred because of logistic reasons or drug shortages.Despite restrictions in the reimbursement policy and accompanying controls in the use of high-cost medicines, the national program enabled treatment of patients with EGFR-mutant NSCLC according to established guidelines. Therefore, the clinical outcomes of such patients treated in Greece during the economic crisis were in accordance with international standards." @default.
- W2893853908 created "2018-10-05" @default.
- W2893853908 creator A5015520718 @default.
- W2893853908 creator A5041575636 @default.
- W2893853908 creator A5044610238 @default.
- W2893853908 creator A5048911584 @default.
- W2893853908 creator A5051365519 @default.
- W2893853908 creator A5061829526 @default.
- W2893853908 creator A5089796322 @default.
- W2893853908 date "2018-12-01" @default.
- W2893853908 modified "2023-09-23" @default.
- W2893853908 title "Treating EGFR-Mutated Oncogene-Addicted Advanced Non–Small-Cell Lung Cancer in the Era of Economic Crisis in Greece: Challenges and Opportunities" @default.
- W2893853908 cites W1505261152 @default.
- W2893853908 cites W1518469225 @default.
- W2893853908 cites W1690635788 @default.
- W2893853908 cites W1757407923 @default.
- W2893853908 cites W1874454018 @default.
- W2893853908 cites W1879169560 @default.
- W2893853908 cites W1913909765 @default.
- W2893853908 cites W1966875510 @default.
- W2893853908 cites W1967394241 @default.
- W2893853908 cites W1972284567 @default.
- W2893853908 cites W1988827171 @default.
- W2893853908 cites W2022572106 @default.
- W2893853908 cites W2101329867 @default.
- W2893853908 cites W2106787323 @default.
- W2893853908 cites W2111662961 @default.
- W2893853908 cites W2114664968 @default.
- W2893853908 cites W2129360604 @default.
- W2893853908 cites W2145835533 @default.
- W2893853908 cites W2149733252 @default.
- W2893853908 cites W2159717588 @default.
- W2893853908 cites W2160982674 @default.
- W2893853908 cites W2163351155 @default.
- W2893853908 cites W2166084034 @default.
- W2893853908 cites W2167191456 @default.
- W2893853908 cites W2168856723 @default.
- W2893853908 cites W2176128299 @default.
- W2893853908 cites W2325642881 @default.
- W2893853908 cites W2530508394 @default.
- W2893853908 cites W2570618306 @default.
- W2893853908 cites W2609638720 @default.
- W2893853908 cites W2758927689 @default.
- W2893853908 cites W646490381 @default.
- W2893853908 doi "https://doi.org/10.1200/jgo.18.00115" @default.
- W2893853908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6223495" @default.
- W2893853908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30260753" @default.
- W2893853908 hasPublicationYear "2018" @default.
- W2893853908 type Work @default.
- W2893853908 sameAs 2893853908 @default.
- W2893853908 citedByCount "0" @default.
- W2893853908 crossrefType "journal-article" @default.
- W2893853908 hasAuthorship W2893853908A5015520718 @default.
- W2893853908 hasAuthorship W2893853908A5041575636 @default.
- W2893853908 hasAuthorship W2893853908A5044610238 @default.
- W2893853908 hasAuthorship W2893853908A5048911584 @default.
- W2893853908 hasAuthorship W2893853908A5051365519 @default.
- W2893853908 hasAuthorship W2893853908A5061829526 @default.
- W2893853908 hasAuthorship W2893853908A5089796322 @default.
- W2893853908 hasBestOaLocation W28938539081 @default.
- W2893853908 hasConcept C121608353 @default.
- W2893853908 hasConcept C126322002 @default.
- W2893853908 hasConcept C143998085 @default.
- W2893853908 hasConcept C160735492 @default.
- W2893853908 hasConcept C162324750 @default.
- W2893853908 hasConcept C195910791 @default.
- W2893853908 hasConcept C207103383 @default.
- W2893853908 hasConcept C2776232967 @default.
- W2893853908 hasConcept C2776256026 @default.
- W2893853908 hasConcept C2778715236 @default.
- W2893853908 hasConcept C2778820342 @default.
- W2893853908 hasConcept C2779134260 @default.
- W2893853908 hasConcept C2779422266 @default.
- W2893853908 hasConcept C2779438470 @default.
- W2893853908 hasConcept C2779703844 @default.
- W2893853908 hasConcept C2780580887 @default.
- W2893853908 hasConcept C44249647 @default.
- W2893853908 hasConcept C50522688 @default.
- W2893853908 hasConcept C71924100 @default.
- W2893853908 hasConceptScore W2893853908C121608353 @default.
- W2893853908 hasConceptScore W2893853908C126322002 @default.
- W2893853908 hasConceptScore W2893853908C143998085 @default.
- W2893853908 hasConceptScore W2893853908C160735492 @default.
- W2893853908 hasConceptScore W2893853908C162324750 @default.
- W2893853908 hasConceptScore W2893853908C195910791 @default.
- W2893853908 hasConceptScore W2893853908C207103383 @default.
- W2893853908 hasConceptScore W2893853908C2776232967 @default.
- W2893853908 hasConceptScore W2893853908C2776256026 @default.
- W2893853908 hasConceptScore W2893853908C2778715236 @default.
- W2893853908 hasConceptScore W2893853908C2778820342 @default.
- W2893853908 hasConceptScore W2893853908C2779134260 @default.
- W2893853908 hasConceptScore W2893853908C2779422266 @default.
- W2893853908 hasConceptScore W2893853908C2779438470 @default.
- W2893853908 hasConceptScore W2893853908C2779703844 @default.
- W2893853908 hasConceptScore W2893853908C2780580887 @default.
- W2893853908 hasConceptScore W2893853908C44249647 @default.
- W2893853908 hasConceptScore W2893853908C50522688 @default.
- W2893853908 hasConceptScore W2893853908C71924100 @default.
- W2893853908 hasLocation W28938539081 @default.
- W2893853908 hasLocation W28938539082 @default.