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- W2893866020 abstract "Retinal ganglion cell apoptosis and optic nerve degeneration are prevalent in aged patients, which may be related to the decrease in bone marrow (BM) stem cell number/function because of the possible cross-talk between the two organs. This pathological process is accelerated by retinal ischaemia-reperfusion (I/R) injury. This study investigated whether young BM stem cells can regenerate and repair the aged retina after acute I/R injury. Young BM stem cell antigen 1 positive (Sca-1+) or Sca-1− cells were transplanted into lethally irradiated aged recipient mice to generate Sca-1+ and Sca-1− chimaeras, respectively. The animals were housed for 3 months to allow the young Sca-1 cells to repopulate in the BM of aged mice. Retinal I/R was then induced by elevation of intraocular pressure. Better preservation of visual function was found in Sca-1+ than Sca-1− chimaeras 7 days after injury. More Sca-1+ cells homed to the retina than Sca-1− cells and more cells differentiated into glial and microglial cells in the Sca-1+ chimaeras. After injury, Sca-1+ cells in the retina reduced host cellular apoptosis, which was associated with higher expression of fibroblast growth factor 2 (FGF2) in the Sca-1+ chimaeras. Young Sca-1+ cells repopulated the stem cells in the aged retina and diminished cellular apoptosis after acute I/R injury through FGF2 and Akt signalling pathways." @default.
- W2893866020 created "2018-10-05" @default.
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- W2893866020 date "2018-09-25" @default.
- W2893866020 modified "2023-10-02" @default.
- W2893866020 title "Young bone marrow Sca-1 cells protect aged retina from ischaemia-reperfusion injury through activation of FGF2" @default.
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- W2893866020 doi "https://doi.org/10.1111/jcmm.13905" @default.
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