Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893868403> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2893868403 abstract "Lipid phosphate phosphatase3 (LPP3) encoded by the PPAP2B gene, is an integral membrane enzyme that degrades bioactive lysophospholipids including lysophosphatidic acid (LPA), sphingosine-1-phosphate (S1P) and related bioactive lipids. These bioactive lipids regulate a wide variety of cellular functions such as proliferation, apoptosis and differentiation. We suggest that LPP3 hydrolysis of LPA is a critical step in regulating pathophysiological important responses in vascular cells. To test this hypothesis, we generated mice lacking LPP3 by breeding Ppap2B fl / fl mice (fl/fl) animals expressing Cre recombinase under control of the SM22 promoter on the LDLr-/- background. At weaning, littermate SM22-Δ and fl/fl mice were fed Western Diet (WD) for 12 weeks. LPP3 expression in aortic SMCs was reduced (0.139 ± 0.0246 vs 1.0 ± 0; P < 0.001) and LPA content was significantly higher (9.32 ± 4.66 vs 5.66 ± 2.65; P < 0.05) in the aortic arch in SM22-Δ mice compared to control fl/fl mice. SM22-Δ mice demonstrated increased atherosclerotic lesions (18.98 ± 7.11% vs 6.06 ± 4.01%; P < 0.001), measured by en face analysis, of the aorta and significantly higher IL-6 expression (18.83 ± 2.87 vs 3.59 ± 8.92; P < 0.05) in the aortic arch. Sections of aorta at the level of the aortic root indicated that the loss of LPP3 upregulate CD68 and α-SMA staining. These results reveal that LPP3 normally functions to suppress atherosclerosis. LPP3 deficiency increases vascular LPA content, may promote the infiltration of inflammatory cells as macrophages into lesions and smooth muscle cell proliferation to accelerate the development of atherosclerosis." @default.
- W2893868403 created "2018-10-05" @default.
- W2893868403 creator A5010812501 @default.
- W2893868403 creator A5060684279 @default.
- W2893868403 creator A5063861589 @default.
- W2893868403 creator A5069878413 @default.
- W2893868403 creator A5070623632 @default.
- W2893868403 date "2016-05-01" @default.
- W2893868403 modified "2023-09-22" @default.
- W2893868403 title "Abstract 467: Lipid Phosphate Phosphatase 3 in Smooth Muscle Cells Suppresses the Development of Atherosclerosis" @default.
- W2893868403 doi "https://doi.org/10.1161/atvb.36.suppl_1.467" @default.
- W2893868403 hasPublicationYear "2016" @default.
- W2893868403 type Work @default.
- W2893868403 sameAs 2893868403 @default.
- W2893868403 citedByCount "0" @default.
- W2893868403 crossrefType "journal-article" @default.
- W2893868403 hasAuthorship W2893868403A5010812501 @default.
- W2893868403 hasAuthorship W2893868403A5060684279 @default.
- W2893868403 hasAuthorship W2893868403A5063861589 @default.
- W2893868403 hasAuthorship W2893868403A5069878413 @default.
- W2893868403 hasAuthorship W2893868403A5070623632 @default.
- W2893868403 hasConcept C126322002 @default.
- W2893868403 hasConcept C134018914 @default.
- W2893868403 hasConcept C160160445 @default.
- W2893868403 hasConcept C178666793 @default.
- W2893868403 hasConcept C181199279 @default.
- W2893868403 hasConcept C185592680 @default.
- W2893868403 hasConcept C2777132085 @default.
- W2893868403 hasConcept C2992686903 @default.
- W2893868403 hasConcept C55493867 @default.
- W2893868403 hasConcept C71924100 @default.
- W2893868403 hasConcept C86803240 @default.
- W2893868403 hasConcept C95444343 @default.
- W2893868403 hasConceptScore W2893868403C126322002 @default.
- W2893868403 hasConceptScore W2893868403C134018914 @default.
- W2893868403 hasConceptScore W2893868403C160160445 @default.
- W2893868403 hasConceptScore W2893868403C178666793 @default.
- W2893868403 hasConceptScore W2893868403C181199279 @default.
- W2893868403 hasConceptScore W2893868403C185592680 @default.
- W2893868403 hasConceptScore W2893868403C2777132085 @default.
- W2893868403 hasConceptScore W2893868403C2992686903 @default.
- W2893868403 hasConceptScore W2893868403C55493867 @default.
- W2893868403 hasConceptScore W2893868403C71924100 @default.
- W2893868403 hasConceptScore W2893868403C86803240 @default.
- W2893868403 hasConceptScore W2893868403C95444343 @default.
- W2893868403 hasLocation W28938684031 @default.
- W2893868403 hasOpenAccess W2893868403 @default.
- W2893868403 hasPrimaryLocation W28938684031 @default.
- W2893868403 hasRelatedWork W159178733 @default.
- W2893868403 hasRelatedWork W1979433262 @default.
- W2893868403 hasRelatedWork W2005823044 @default.
- W2893868403 hasRelatedWork W2017050322 @default.
- W2893868403 hasRelatedWork W2025191509 @default.
- W2893868403 hasRelatedWork W2040620918 @default.
- W2893868403 hasRelatedWork W2053976891 @default.
- W2893868403 hasRelatedWork W2061430401 @default.
- W2893868403 hasRelatedWork W2078533360 @default.
- W2893868403 hasRelatedWork W2081141873 @default.
- W2893868403 hasRelatedWork W2084952393 @default.
- W2893868403 hasRelatedWork W2104794184 @default.
- W2893868403 hasRelatedWork W210912030 @default.
- W2893868403 hasRelatedWork W2123274906 @default.
- W2893868403 hasRelatedWork W2171160774 @default.
- W2893868403 hasRelatedWork W2378459715 @default.
- W2893868403 hasRelatedWork W2810266890 @default.
- W2893868403 hasRelatedWork W2893718808 @default.
- W2893868403 hasRelatedWork W3021444955 @default.
- W2893868403 hasRelatedWork W3198072737 @default.
- W2893868403 isParatext "false" @default.
- W2893868403 isRetracted "false" @default.
- W2893868403 magId "2893868403" @default.
- W2893868403 workType "article" @default.