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• W2893868684 abstract "Abstract Background Neuroimmune interactions are essential to maintain gut homeostasis and prevent intestinal disorders but so far, the impact of enteric glial cells (EGC) on immune cells remains a relatively unexplored area of research. As a dysregulation of critical cytokines such as interleukine‐7 (IL‐7) was suggested to exacerbate gut chronic inflammation, we investigated whether EGC could be a source of IL‐7 in the gastrointestinal tract. Methods Expression of IL‐7 in the rat enteric nervous system was analyzed by immunochemistry and Q‐PCR. IL‐7 variants were cloned and specific antibodies against rat IL‐7 isoforms were raised to characterize their expression in the submucosal plexus. IL‐7 isoforms were produced in vitro to analyze their impact on T‐cell survival. Key Results Neurons and glial cells of the rat enteric nervous system expressed IL‐7 at both mRNA and protein levels. Novel rat IL‐7 isoforms with distinct C‐terminal parts were detected. Three of these isoforms were found in EGC or in both enteric neurons and EGC. Exposure of EGC to pro‐inflammatory cytokines (IL‐1β and/or TNFα) induced an upregulation of all IL‐7 isoforms. Interestingly, time‐course and intensity of the upregulation varied according to the presence or absence of exon 5a in IL‐7 variants. Functional analysis on T lymphocytes revealed that only canonical IL‐7 protects T cells from cell death. Conclusions and Inferences IL‐7 and its variants are expressed by neurons and glial cells in the enteric nervous system. Their distinct expression and upregulation in inflammatory conditions suggest a role in gut homeostasis which could be critical in case of chronic inflammatory diseases." @default.
• W2893868684 created "2018-10-05" @default.
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• W2893868684 date "2018-09-21" @default.
• W2893868684 modified "2023-10-14" @default.
• W2893868684 title "Rat enteric glial cells express novel isoforms of Interleukine‐7 regulated during inflammation" @default.
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• W2893868684 doi "https://doi.org/10.1111/nmo.13467" @default.
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• W2893868684 hasPublicationYear "2018" @default.
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