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- W2893868814 abstract "Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma (HCC) since 2007 and numerous studies have investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC." @default.
- W2893868814 created "2018-10-05" @default.
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- W2893868814 date "2018-09-28" @default.
- W2893868814 modified "2023-10-17" @default.
- W2893868814 title "Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?" @default.
- W2893868814 cites W1486451451 @default.
- W2893868814 cites W1522860394 @default.
- W2893868814 cites W1563776571 @default.
- W2893868814 cites W1801847674 @default.
- W2893868814 cites W1892405924 @default.
- W2893868814 cites W1919200564 @default.
- W2893868814 cites W1947415419 @default.
- W2893868814 cites W1964873462 @default.
- W2893868814 cites W1964991674 @default.
- W2893868814 cites W1966533693 @default.
- W2893868814 cites W1967447165 @default.
- W2893868814 cites W1971837077 @default.
- W2893868814 cites W1978612707 @default.
- W2893868814 cites W1988508343 @default.
- W2893868814 cites W1989647054 @default.
- W2893868814 cites W1989892577 @default.
- W2893868814 cites W1996834135 @default.
- W2893868814 cites W2000774941 @default.
- W2893868814 cites W2019607817 @default.
- W2893868814 cites W2024450952 @default.
- W2893868814 cites W2029658107 @default.
- W2893868814 cites W2037286749 @default.
- W2893868814 cites W2040970018 @default.
- W2893868814 cites W2046718226 @default.
- W2893868814 cites W2051664495 @default.
- W2893868814 cites W2057559442 @default.
- W2893868814 cites W2061746936 @default.
- W2893868814 cites W2063086242 @default.
- W2893868814 cites W2070489177 @default.
- W2893868814 cites W2079358014 @default.
- W2893868814 cites W2083825173 @default.
- W2893868814 cites W2085299433 @default.
- W2893868814 cites W2089658993 @default.
- W2893868814 cites W2094049211 @default.
- W2893868814 cites W2102942095 @default.
- W2893868814 cites W2104630532 @default.
- W2893868814 cites W2107934474 @default.
- W2893868814 cites W2109479504 @default.
- W2893868814 cites W2111070218 @default.
- W2893868814 cites W2119182224 @default.
- W2893868814 cites W2122074158 @default.
- W2893868814 cites W2124927243 @default.
- W2893868814 cites W2128153851 @default.
- W2893868814 cites W2130756184 @default.
- W2893868814 cites W2136269710 @default.
- W2893868814 cites W2138877493 @default.
- W2893868814 cites W2139248078 @default.
- W2893868814 cites W2142020092 @default.
- W2893868814 cites W2152033211 @default.
- W2893868814 cites W2156871508 @default.
- W2893868814 cites W2159044489 @default.
- W2893868814 cites W2159183306 @default.
- W2893868814 cites W2164241627 @default.
- W2893868814 cites W2168742889 @default.
- W2893868814 cites W2174734259 @default.
- W2893868814 cites W2240829153 @default.
- W2893868814 cites W2294314163 @default.
- W2893868814 cites W2322546964 @default.
- W2893868814 cites W2341538586 @default.
- W2893868814 cites W2502891277 @default.
- W2893868814 cites W2507149438 @default.
- W2893868814 cites W2521536219 @default.
- W2893868814 cites W2550957319 @default.
- W2893868814 cites W2564550211 @default.
- W2893868814 cites W2564770039 @default.
- W2893868814 cites W2574465504 @default.
- W2893868814 cites W2588594032 @default.
- W2893868814 cites W2590844788 @default.
- W2893868814 cites W2593934723 @default.
- W2893868814 cites W2594017621 @default.
- W2893868814 cites W2601668589 @default.
- W2893868814 cites W2611336716 @default.
- W2893868814 cites W2614534967 @default.
- W2893868814 cites W2727497670 @default.
- W2893868814 cites W2741672967 @default.
- W2893868814 cites W2751497219 @default.
- W2893868814 cites W2761349898 @default.
- W2893868814 cites W2762942199 @default.
- W2893868814 cites W2771730406 @default.
- W2893868814 cites W2780943091 @default.