Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893869225> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2893869225 endingPage "20" @default.
- W2893869225 startingPage "14" @default.
- W2893869225 abstract "The RUNX1-EVI1 gene generated by the t(3;21) translocation encodes a chimeric transcription factor and is a causative gene in the development of de novo acute megakaryoblastic leukemia and leukemic transformation of hematopoietic stem cell tumors. Heterozygous RUNX1-EVI1 knock-in mice die in utero due to hemorrhage in the central nervous system and spinal cord and complete abolishment of definitive hematopoiesis in the fetal liver. On the other hand, the chimeric knock-in mouse develops acute megakaryoblastic leukemia. We created another mouse model of RUNX1-EVI1 using transplantation of retrovirus-infected bone marrow cells. Some mice transplanted with RUNX1-EVI1-expressing bone marrow cells developed acute megakaryoblastic leukemia within eight months, and the other non-leukemic mice showed thrombocytosis at around a year. In the non-leukemic mice, dysplastic megakaryocytes proliferated in the bone marrow and frequently infiltrated into the spleen, which was not associated with marrow fibrosis. In the leukemic mice, their tumor cells were positive for c-kit and CD41, and negative for TER119. Although they were negative for platelet peroxidase in the electron microscopic analysis, they had multiple centrioles in the cytoplasm, which are characteristic of megakaryocytes that undergo endomitosis. The leukemic cells were serially transplantable, and gene-expression analyses using quantitative RT-PCR arrays revealed that they showed significantly elevated expression of stem cell, primitive hematopoietic cell and endothelial cell-related genes compared with normal bone marrow cells. All these data suggested that RUNX1-EVI1 caused dysplastic hematopoiesis or leukemia of the megakaryocytic lineage and endowed gene expression profiles distinctive of immature hematopoietic cells." @default.
- W2893869225 created "2018-10-05" @default.
- W2893869225 creator A5023359954 @default.
- W2893869225 creator A5027375742 @default.
- W2893869225 creator A5050827716 @default.
- W2893869225 creator A5070857376 @default.
- W2893869225 creator A5080139193 @default.
- W2893869225 creator A5090016849 @default.
- W2893869225 date "2018-11-01" @default.
- W2893869225 modified "2023-09-24" @default.
- W2893869225 title "RUNX1-EVI1 induces dysplastic hematopoiesis and acute leukemia of the megakaryocytic lineage in mice" @default.
- W2893869225 cites W1532921008 @default.
- W2893869225 cites W1578441131 @default.
- W2893869225 cites W1968450434 @default.
- W2893869225 cites W1981764642 @default.
- W2893869225 cites W1991766825 @default.
- W2893869225 cites W2012847858 @default.
- W2893869225 cites W2015474402 @default.
- W2893869225 cites W2016420793 @default.
- W2893869225 cites W2068592712 @default.
- W2893869225 cites W2080309772 @default.
- W2893869225 cites W2084535571 @default.
- W2893869225 cites W2085033687 @default.
- W2893869225 cites W2160863166 @default.
- W2893869225 cites W2171915984 @default.
- W2893869225 cites W2314359937 @default.
- W2893869225 cites W4236296592 @default.
- W2893869225 doi "https://doi.org/10.1016/j.leukres.2018.09.015" @default.
- W2893869225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30278283" @default.
- W2893869225 hasPublicationYear "2018" @default.
- W2893869225 type Work @default.
- W2893869225 sameAs 2893869225 @default.
- W2893869225 citedByCount "4" @default.
- W2893869225 countsByYear W28938692252019 @default.
- W2893869225 countsByYear W28938692252022 @default.
- W2893869225 countsByYear W28938692252023 @default.
- W2893869225 crossrefType "journal-article" @default.
- W2893869225 hasAuthorship W2893869225A5023359954 @default.
- W2893869225 hasAuthorship W2893869225A5027375742 @default.
- W2893869225 hasAuthorship W2893869225A5050827716 @default.
- W2893869225 hasAuthorship W2893869225A5070857376 @default.
- W2893869225 hasAuthorship W2893869225A5080139193 @default.
- W2893869225 hasAuthorship W2893869225A5090016849 @default.
- W2893869225 hasConcept C109159458 @default.
- W2893869225 hasConcept C142724271 @default.
- W2893869225 hasConcept C153911025 @default.
- W2893869225 hasConcept C203014093 @default.
- W2893869225 hasConcept C2776863199 @default.
- W2893869225 hasConcept C2778193527 @default.
- W2893869225 hasConcept C2778378607 @default.
- W2893869225 hasConcept C2778461978 @default.
- W2893869225 hasConcept C2779705218 @default.
- W2893869225 hasConcept C2780007613 @default.
- W2893869225 hasConcept C28328180 @default.
- W2893869225 hasConcept C502942594 @default.
- W2893869225 hasConcept C71924100 @default.
- W2893869225 hasConcept C86803240 @default.
- W2893869225 hasConcept C95444343 @default.
- W2893869225 hasConceptScore W2893869225C109159458 @default.
- W2893869225 hasConceptScore W2893869225C142724271 @default.
- W2893869225 hasConceptScore W2893869225C153911025 @default.
- W2893869225 hasConceptScore W2893869225C203014093 @default.
- W2893869225 hasConceptScore W2893869225C2776863199 @default.
- W2893869225 hasConceptScore W2893869225C2778193527 @default.
- W2893869225 hasConceptScore W2893869225C2778378607 @default.
- W2893869225 hasConceptScore W2893869225C2778461978 @default.
- W2893869225 hasConceptScore W2893869225C2779705218 @default.
- W2893869225 hasConceptScore W2893869225C2780007613 @default.
- W2893869225 hasConceptScore W2893869225C28328180 @default.
- W2893869225 hasConceptScore W2893869225C502942594 @default.
- W2893869225 hasConceptScore W2893869225C71924100 @default.
- W2893869225 hasConceptScore W2893869225C86803240 @default.
- W2893869225 hasConceptScore W2893869225C95444343 @default.
- W2893869225 hasFunder F4320334764 @default.
- W2893869225 hasLocation W28938692251 @default.
- W2893869225 hasLocation W28938692252 @default.
- W2893869225 hasOpenAccess W2893869225 @default.
- W2893869225 hasPrimaryLocation W28938692251 @default.
- W2893869225 hasRelatedWork W1966177375 @default.
- W2893869225 hasRelatedWork W1988496118 @default.
- W2893869225 hasRelatedWork W2053487253 @default.
- W2893869225 hasRelatedWork W2063990364 @default.
- W2893869225 hasRelatedWork W2089904379 @default.
- W2893869225 hasRelatedWork W2413089402 @default.
- W2893869225 hasRelatedWork W2737200409 @default.
- W2893869225 hasRelatedWork W2893869225 @default.
- W2893869225 hasRelatedWork W2912930432 @default.
- W2893869225 hasRelatedWork W4210379329 @default.
- W2893869225 hasVolume "74" @default.
- W2893869225 isParatext "false" @default.
- W2893869225 isRetracted "false" @default.
- W2893869225 magId "2893869225" @default.
- W2893869225 workType "article" @default.