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- W2893881231 startingPage "64" @default.
- W2893881231 abstract "The ubiquitin proteasome system (UPS) is the major pathway for intracellular protein degradation in most organs, including the heart. UPS controls many fundamental biological processes such as cell cycle, cell division, immune responses, antigen presentation, apoptosis, and cell signaling. The UPS not only degrades substrates but also regulates activity of gene transcription at the post-transcription level. Emerging evidence suggests that impairment of UPS function is sufficient to cause a number of cardiac diseases, including heart failure, cardiomyopathies, hypertrophy, atrophy, ischemia-reperfusion, and atherosclerosis. Alterations in the expression of UPS components, changes in proteasomal peptidase activities and increased ubiquitinated and oxidized proteins have also been detected in diabetic cardiomyopathy (DCM). However, the pathophysiological role of the UPS in DCM has not been examined. Recently, in vitro and in vivo studies have proven highly valuable in assessing effects of various stressors on the UPS and, in some cases, suggesting a causal link between defective protein clearance and disease phenotypes in different cardiac diseases, including DCM. Translation of these findings to human disease can be greatly strengthened by corroboration of discoveries from experimental model systems using human heart tissue from well-defined patient populations. This review will summarize the general role of the UPS in different cardiac diseases, with major focus on DCM, and on recent advances in therapeutic development." @default.
- W2893881231 created "2018-10-05" @default.
- W2893881231 creator A5022441636 @default.
- W2893881231 creator A5082964755 @default.
- W2893881231 date "2019-03-01" @default.
- W2893881231 modified "2023-09-29" @default.
- W2893881231 title "Proteasome biology and therapeutics in cardiac diseases" @default.
- W2893881231 cites W14233263 @default.
- W2893881231 cites W1462003177 @default.
- W2893881231 cites W1513460209 @default.
- W2893881231 cites W1556287360 @default.
- W2893881231 cites W1561890261 @default.
- W2893881231 cites W1565667884 @default.
- W2893881231 cites W1568006607 @default.
- W2893881231 cites W1591106227 @default.
- W2893881231 cites W1609254757 @default.
- W2893881231 cites W1661548638 @default.
- W2893881231 cites W1782287000 @default.
- W2893881231 cites W1964416938 @default.
- W2893881231 cites W1966333337 @default.
- W2893881231 cites W1966826178 @default.
- W2893881231 cites W1968883331 @default.
- W2893881231 cites W1968975143 @default.
- W2893881231 cites W1970351187 @default.
- W2893881231 cites W1974501072 @default.
- W2893881231 cites W1978221635 @default.
- W2893881231 cites W1980124970 @default.
- W2893881231 cites W1980585420 @default.
- W2893881231 cites W1981614332 @default.
- W2893881231 cites W1982380248 @default.
- W2893881231 cites W1985453440 @default.
- W2893881231 cites W1986040594 @default.
- W2893881231 cites W1987922405 @default.
- W2893881231 cites W1992427679 @default.
- W2893881231 cites W1993983296 @default.
- W2893881231 cites W2004147995 @default.
- W2893881231 cites W2005859751 @default.
- W2893881231 cites W2006499762 @default.
- W2893881231 cites W2013271791 @default.
- W2893881231 cites W2017969831 @default.
- W2893881231 cites W2019851303 @default.
- W2893881231 cites W2020309422 @default.
- W2893881231 cites W2020552978 @default.
- W2893881231 cites W2021366027 @default.
- W2893881231 cites W2022483455 @default.
- W2893881231 cites W2023701632 @default.
- W2893881231 cites W2029013337 @default.
- W2893881231 cites W2032578967 @default.
- W2893881231 cites W2034688591 @default.
- W2893881231 cites W2035892035 @default.
- W2893881231 cites W2037386069 @default.
- W2893881231 cites W2039144261 @default.
- W2893881231 cites W2048915877 @default.
- W2893881231 cites W2051458654 @default.
- W2893881231 cites W2051718218 @default.
- W2893881231 cites W2053450572 @default.
- W2893881231 cites W2053634523 @default.
- W2893881231 cites W2054655694 @default.
- W2893881231 cites W2054883000 @default.
- W2893881231 cites W2057318044 @default.
- W2893881231 cites W2057491765 @default.
- W2893881231 cites W2060063018 @default.
- W2893881231 cites W2064417575 @default.
- W2893881231 cites W2080346452 @default.
- W2893881231 cites W2081356823 @default.
- W2893881231 cites W2081545299 @default.
- W2893881231 cites W2081992157 @default.
- W2893881231 cites W2082050214 @default.
- W2893881231 cites W2082231490 @default.
- W2893881231 cites W2087168227 @default.
- W2893881231 cites W2091958169 @default.
- W2893881231 cites W2092575722 @default.
- W2893881231 cites W2092974070 @default.
- W2893881231 cites W2093598492 @default.
- W2893881231 cites W2093861673 @default.
- W2893881231 cites W2094442466 @default.
- W2893881231 cites W2096980800 @default.
- W2893881231 cites W2097094654 @default.
- W2893881231 cites W2098076627 @default.
- W2893881231 cites W2098787491 @default.
- W2893881231 cites W2100041921 @default.
- W2893881231 cites W2100651399 @default.
- W2893881231 cites W2100826259 @default.
- W2893881231 cites W2101877908 @default.
- W2893881231 cites W2102784194 @default.
- W2893881231 cites W2103460528 @default.
- W2893881231 cites W2103671547 @default.
- W2893881231 cites W2103822936 @default.
- W2893881231 cites W2106071043 @default.
- W2893881231 cites W2106278833 @default.
- W2893881231 cites W2107447005 @default.
- W2893881231 cites W2107840570 @default.
- W2893881231 cites W2108904800 @default.
- W2893881231 cites W2109712401 @default.
- W2893881231 cites W2112079611 @default.
- W2893881231 cites W2113603422 @default.
- W2893881231 cites W2116053081 @default.
- W2893881231 cites W2116756051 @default.