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• W2893882113 abstract "Tofacitinib is a Janus activated kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis and active psoriatic arthritis. Its synthesis normally involves long synthetic sequences due to the chirality associated to the piperidine ring. This review is a comprehensive analysis of the different synthetic methods used to prepare this active pharmaceutical ingredient (API), covering the related journal and patent literature." @default.
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• W2893882113 date "2018-11-29" @default.
• W2893882113 modified "2023-09-27" @default.
• W2893882113 title "Tofacitinib Synthesis – An Asymmetric Challenge" @default.
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• W2893882113 doi "https://doi.org/10.1002/ejoc.201801180" @default.
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