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• W2893885963 abstract "Understanding the behavior of proteins at material interfaces has become increasingly important as the intersection between the biological and synthetic worlds continues to grow. By inducing changes in protein structure, interactions with materials may lead to a loss of function and/or biological activity, as well as undesirable cellular interactions in vivo, including the foreign body reaction to implantable materials. Despite extensive research, the understanding of the mechanisms that lead to protein conformational changes on surfaces remains incomplete. Here, we highlight recent advances in understanding and controlling protein conformation on the surface of synthetic materials, including nanomaterials, polymer films and brushes, metal coatings and particles, and graphitic materials. We also review developments in the use of biophysical and computational methods for characterizing the structure of proteins at solution–solid interfaces. These approaches have provided important new insights into the physico-chemical factors that control protein conformation in near-surface environments, which represents a critical step towards the rational design of biotic–abiotic interfaces in biomedical and biotechnological applications." @default.
• W2893885963 created "2018-10-05" @default.
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• W2893885963 date "2018-11-01" @default.
• W2893885963 modified "2023-10-18" @default.
• W2893885963 title "Impact of surface interactions on protein conformation" @default.
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• W2893885963 doi "https://doi.org/10.1016/j.cocis.2018.08.002" @default.
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